4-methylphenyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-methylphenyl 3,5-dimethyl-1-phenyl-1H-pyrazole-4-carboxylate
• 英文别名: (4-methylphenyl) 3,5-dimethyl-1-phenylpyrazole-4-carboxylate
• 化学式: C₁₉H₁₈N₂O₂
• 分子量: 306.4
• InChiKey: HWVVEWNZEAKFSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  44.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Cyclic AMP-specific phosphodiesterase inhibitors
  申请人：ICOS Corporation

  公开号：US20030236412A1

  公开（公告）日：2003-12-25

  Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

  本发明公开了一种强效和选择性的PDE4抑制剂吡唑化合物，以及制备这些化合物的方法。本发明还公开了这些化合物在治疗炎症性疾病和其他涉及细胞因子水平升高的疾病以及中枢神经系统（CNS）疾病中的应用。
• PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS
  申请人：ICOS CORPORATION

  公开号：EP1248781A1

  公开（公告）日：2002-10-16
• US6569885B1
  申请人：——

  公开号：US6569885B1

  公开（公告）日：2003-05-27
• US7087634B2
  申请人：——

  公开号：US7087634B2

  公开（公告）日：2006-08-08
• [EN] PYRAZOLE CYCLIC AMP-SPECIFIC PDE INHIBITORS<br/>[FR] INHIBITEURS DE LA PHOSPHODIESTERASE SPECIFIQUE DE L'ADENOSINE MONOPHOSPHATE CYCLIQUE PYRAZOLIQUE
  申请人：ICOS CORP

  公开号：WO2001046172A1

  公开（公告）日：2001-06-28

  Pyrazole compounds (I) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed (I) wherein Y is O or NOH; Z is O or NH; R1 - R4 are as claimed.