3-Fluoro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-YL]benzenesulfonamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-Fluoro-N-[1-(4-fluorophenyl)-3-(2-thienyl)-1H-pyrazol-5-YL]benzenesulfonamide
• 英文别名: 3-fluoro-N-[2-(4-fluorophenyl)-5-thiophen-2-ylpyrazol-3-yl]benzenesulfonamide
• 化学式: C₁₉H₁₃F₂N₃O₂S₂
• 分子量: 417.5
• InChiKey: GULUFDCOGAXLEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• AGENTS FOR TREATMENT OF ALCOHOL USE DISORDER
  申请人：Servicio Andaluz de Salud

  公开号：EP3834888A2

  公开（公告）日：2021-06-16

  The present invention relates to the use of PPARα agonist compounds for preventing, alleviating, improving and/or treating alcohol use disorder.

  本发明涉及 PPARα 激动剂化合物在预防、减轻、改善和/或治疗酒精使用障碍方面的用途。
• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• IDENTIFICATION AND TARGETED MODULATION OF GENE SIGNALING NETWORKS
  申请人：CAMP4 THERAPEUTICS CORPORATION

  公开号：US20210254056A1

  公开（公告）日：2021-08-19

  The present invention provides methods and compositions for the evaluation, alteration and/or optimization of gene signaling. Methods and systems are also provided which exploit the information generated in the identification of new targets and non-canonical signaling pathways.
• [EN] AGENTS FOR TREATMENT OF ALCOHOL USE DISORDER<br/>[ES] AGENTES PARA EL TRATAMIENTO DEL TRASTORNO POR USO DE ALCOHOL<br/>[FR] AGENTS POUR LE TRAITEMENT DU TROUBLE LIÉ À LA CONSOMMATION D'ALCOOL
  申请人：SERVICIO ANDALUZ DE SALUD

  公开号：WO2020030843A2

  公开（公告）日：2020-02-13

  La presente invención se refiere al uso de compuestos agonistas PPARα para la prevención, alivio, mejora y/o tratamiento del trastorno por uso de alcohol.