3,3'-diethyl-3'-hydroxy-1,1'-dimethyl-[3,5'-biindoline]-2,2'-dione | 1335243-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,3'-diethyl-3'-hydroxy-1,1'-dimethyl-[3,5'-biindoline]-2,2'-dione
• 英文别名: 3-Ethyl-5-(3-ethyl-1-methyl-2-oxoindol-3-yl)-3-hydroxy-1-methylindol-2-one；3-ethyl-5-(3-ethyl-1-methyl-2-oxoindol-3-yl)-3-hydroxy-1-methylindol-2-one
• CAS: 1335243-10-1
• 化学式: C₂₂H₂₄N₂O₃
• 分子量: 364.444
• InChiKey: PMELOLINZHFUSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲基-2-氧代-N-苯基丁酰胺 在 三氟乙酸 、 水 、 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 生成 3,3'-diethyl-3'-hydroxy-1,1'-dimethyl-[3,5'-biindoline]-2,2'-dione
  参考文献：
  名称：

  Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-N-Anilides

  摘要：

  Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions,

  DOI：

  10.1021/ol202263a

文献信息

• Trifluoroacetic Acid-Promoted Synthesis of 3-Hydroxy, 3-Amino and Spirooxindoles from α-Keto-<i>N</i>-Anilides
  作者：Ioulia Gorokhovik、Luc Neuville、Jieping Zhu

  DOI：10.1021/ol202263a

  日期：2011.10.21

  Ketoanilides containing alkyl side chains were readily cyclized to 3-hydroxy-2-oxindoles or spirooxindoles by a single or double intramolecular Friedel-Crafts reaction in the presence of trifluoroacetic acid (TFA) at room temperature or at 45 degrees C. alpha-Iminocarboxamides, generated in situ from ketoamides, cyclized similarly to 3-aminooxindoles under identical conditions,