2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole | 318234-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-phenyl-5-(1H-pyrazol-3-yl)-1,3-thiazole
• 英文别名: 2-phenyl-5-(1H-pyrazol-5-yl)-1,3-thiazole
• CAS: 318234-44-5
• 化学式: C₁₂H₉N₃S
• 分子量: 227.29
• InChiKey: NRAHRUHGPGBWSI-UHFFFAOYSA-N

物化性质

• 熔点：
  240-243°

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.8
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险等级：
  IRRITANT

文献信息

• [EN] 3,4-DISUBSTITUTED 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK<br/>[FR] INHIBITEURS 3,4-DISUBSTITUÉ 1H-PYRAZOLE ET 4,5-DISUBSTITUÉ THIAZOLE DE SYK
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014064134A1

  公开（公告）日：2014-05-01

  The present invention relates to the use of novel compounds of formula (I), wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用式(I)的新化合物，其中所有可变取代基如本文所述，这些化合物是SYK抑制剂，可用于治疗自身免疫和炎症性疾病。
• METHOD FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  申请人：Maxey Kirk W.

  公开号：US20090286261A1

  公开（公告）日：2009-11-19

  An exemplary embodiment may be directed to a fluorescence polarization assay that screens compounds or agents for their affinity to hematopoietic prostaglandin D synthase (H-PGDS) based on their ability to displace a fluorophore-containing detection analyte bound to an enzyme comprising the primary amino acid sequence of H-PGDS. Another exemplary embodiment utilizes an enzyme having a maltose binding protein amino-acid sequence fused with an N-terminus of the enzyme.

  一个示范性实施例可能涉及一种荧光极化测定法，该方法通过检测化合物或试剂对血液造血素D合成酶（H-PGDS）的亲和力来筛选，其基于它们能够将结合到具有H-PGDS主要氨基酸序列的酶上的含荧光团的检测分析物位移开。另一个示范性实施例利用具有麦芽糖结合蛋白氨基酸序列的酶，与酶的N-末端融合。
• 1 H-PYRAZOLE AND 4,5-DISUBSTITUTED THIAZOLE INHIBITORS OF SYK
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150266874A1

  公开（公告）日：2015-09-24

  The present invention relates to the use of novel compounds of formula (I), wherein all variable substituents are defined as described herein, which are SYK inhibitors and are useful for the treatment of auto-immune and inflammatory diseases.

  本发明涉及使用式(I)的新化合物，其中所有变量取代基如本文所述，它们是SYK抑制剂，用于治疗自身免疫和炎症性疾病。
• METHODS FOR ASSAYING COMPOUNDS OR AGENTS FOR ABILITY TO DISPLACE POTENT LIGANDS OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE
  申请人：Cayman Chemical Company

  公开号：EP2286221A2

  公开（公告）日：2011-02-23
• HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS
  申请人：The University Of Queensland

  公开号：EP2576536B1

  公开（公告）日：2016-09-14