5-ethyl-1H-pyrazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-ethyl-1H-pyrazole-4-carboxamide
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: OKJCUMRVHNMASJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] COMPOUNDS USEFUL AS KINASE INHIBITORS<br/>[FR] COMPOSÉS UTILISÉS COMME INHIBITEURS DE KINASE
  申请人：REDX PHARMA PLC

  公开号：WO2017103611A1

  公开（公告）日：2017-06-22

  This invention relates to novel compounds. The compounds of the invention are tyrosine kinase inhibitors. Specifically, the compounds of the invention are useful as inhibitors of Bruton's tyrosine kinase (BTK).The invention also contemplates the use of the compounds for treating conditions treatable by the inhibition of Bruton's tyrosine kinase, for example cancer, lymphoma, leukemia and immunological diseases.

  这项发明涉及新颖的化合物。该发明的化合物是酪氨酸激酶抑制剂。具体来说，该发明的化合物可用作布鲁顿氏酪氨酸激酶（BTK）的抑制剂。该发明还考虑了利用这些化合物治疗通过抑制布鲁顿氏酪氨酸激酶可治疗的疾病，例如癌症、淋巴瘤、白血病和免疫性疾病。
• Compositions and methods for inhibiting kinases
  申请人：Inhibikase Therapeutics, Inc.

  公开号：US10906896B2

  公开（公告）日：2021-02-02

  The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention provides compositions and methods for using these compounds and compositions in the prevention or treatment of cancer or a bacterial or viral infection in a subject.

  本发明提供了用于预防或治疗癌症或细菌或病毒感染的化合物。此外，本发明还提供了使用这些化合物和组合物预防或治疗癌症或受试者的细菌或病毒感染的组合物和方法。
• COMPOUNDS USEFUL AS KINASE INHIBITORS
  申请人：Loxo Oncology Inc.

  公开号：EP3390395A1

  公开（公告）日：2018-10-24
• HETEROCYCLEN-DERIVATE ALS SCHÄDLINGSBEKÄMPFUNGSMITTEL
  申请人：Bayer Aktiengesellschaft

  公开号：EP3814346A1

  公开（公告）日：2021-05-05
• COMPOSITIONS AND METHODS FOR INHIBITING KINASES
  申请人：Inhibikase Therapeutics, Inc.

  公开号：US20180057488A1

  公开（公告）日：2018-03-01

  The present invention provides compounds for the prevention or treatment of cancer or a bacterial or viral infection. Additionally, the present invention provides compositions and methods for using these compounds and compositions in the prevention or treatment of cancer or a bacterial or viral infection in a subject.