5-chloro-N-isopropyl-1-methyl-1H-pyrazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-chloro-N-isopropyl-1-methyl-1H-pyrazole-4-carboxamide
• 英文别名: 5-chloro-1-methyl-N-propan-2-ylpyrazole-4-carboxamide
• 化学式: C₈H₁₂ClN₃O
• mdl: MFCD02089683
• 分子量: 201.65
• InChiKey: XIJZMYRMOZZHRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] INHIBITORS OF PEPTIDYLARGININE DEIMINASES<br/>[FR] INHIBITEURS DE PEPTIDYLARGININE DÉIMINASES
  申请人：[en]GILEAD SCIENCES, INC.

  公开号：WO2022140428A2

  公开（公告）日：2022-06-30

  The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.