phenylglycine butyl ester | 91304-82-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylglycine butyl ester
• 英文别名: butyl-N-phenyl glycinate；butyl 2-anilinoacetate
• CAS: 91304-82-4
• 化学式: C₁₂H₁₇NO₂
• mdl: MFCD12148606
• 分子量: 207.272
• InChiKey: GZWRQDVFLUPFCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenylglycine butyl ester 、 4-(氟磺酰)苯酰氯 以 吡啶 为溶剂， 生成 butyl-N-phenyl-N-p-fluorosulfonylbenzoyl glycinate
  参考文献：
  名称：

  Method for inhibiting the growth of fungi with phenyl glycine compounds

  摘要：

  本发明揭示了一种用于抑制真菌生长的新化合物和方法，包括将所述真菌与下式的苯基甘氨酸化合物接触，其中R.sub.1和R.sub.2分别独立地是氢、较低烷基、取代的较低烷基、环烷基、取代的环烷基、烯烃基、苯基、取代的苯基、卤素、氨基或羟基基团；R.sub.3是氢、较低烷基、取代的较低烷基、环烷基、苯甲酰基、卤素或硝基取代的苯甲酰基、取代的环烷基、甲基氨基甲酰基、环己基氨基甲酰基、苯基氨基甲酰基、卤代苯基氨基甲酰基、甲基苯基氨基甲酰基、甲硫氨基甲酰基、苯基、取代的苯基、萘基或--SO.sub.2R.sub.7，其中R.sub.7是氢、烷基、取代的烷基、苯基、取代的苯基或氨基；R.sub.4和R.sub.5分别是氢、较低烷基或取代的较低烷基基团，R.sub.6是氢、较低烷基或取代的较低烷基、烯烃基或取代的烯烃基。

  公开号：

  US04492683A1
• 作为产物：
  描述：

  苯胺 、 乙醛酸正丁酯 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 1,2-二氯乙烷 为溶剂， 生成 phenylglycine butyl ester
  参考文献：
  名称：

  Cardioselective Antiischemic ATP-Sensitive Potassium Channel (K_ATP) Openers. 5. Identification of 4-(N-Aryl)-Substituted Benzopyran Derivatives with High Selectivity

  摘要：

  This paper describes our studies aimed at the discovery of structurally distinct analogs of the cardioprotective K-ATP Opener BMS-180448 (2) with improved selectivity for the ischemic myocardium. The starting compound 6, derived from the indole analog 4, showed good cardioprotective potency and excellent selectivity compared to 2 and the first-generation K-ATP opener cromakalim (1). The structure-activity studies indicate that increasing the size of the alkyl ester leads to diminished potency as does its replacement with a variety of other groups (nitrile, methyl sulfone). Replacement of the ethyl ester of 6 with an imidazole gave the best compound 3 (BMS-191095) of this series which maintains the potency and selectivity of its predecessor 6. The results described in this publication further support that there is no correlation between vasorelaxant and cardioprotective potencies of K-ATP openers. Compound 3 is over 20- and 4000-fold more selective far the ischemic myocardium than 2 and cromakalim (1), respectively. The selectivity for the ischemic myocardium is achieved by reduction of vasorelaxant potency rather than enhancement in antiischemic potency. As for cromakalim (1) and 2, the cardioprotective effects of compound 3 are inhibited by cotreatment with the K-ATP blocker glyburide, indicating that the K-ATP Opening is involved in its mechanism of cardioprotection With its good oral bioavailability (47%) and plasma elimination half life (3 h) in rats, compound 3 offers an excellent candidate to investigate the role of residual vasorelaxant potency of 2 toward its cardioprotective activity in vivo.

  DOI：

  10.1021/jm9605905

文献信息

• Resolution of racemic mandelic acid
  申请人：Kay Fries, Inc.

  公开号：US04322548A1

  公开（公告）日：1982-03-30

  Process for the optical resolution of racemic mandelic acid which process comprises contacting said racemic mandelic acid with a phenylglycine ester or a phenylglycine ester hydrochloride in a reaction medium, and recovering the D(-)-mandelic acid and L(+)-mandelic acid form; certain D(-) and L(+)-phenylglycine esters and hydrochlorides are provided as novel resolution agents.

  光学分辨对于混合的苯甘酸的过程包括将该混合的苯甘酸与苯基甘氨酸酯或苯基甘氨酸酯盐酸盐在反应介质中接触，并回收D（-）-苯甘酸和L（+）-苯甘酸形式; 提供某些D（-）和L（+）-苯基甘氨酸酯及其盐酸盐作为新的分辨剂。
• Process for the preparation of clavulanic acid
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0672670A1

  公开（公告）日：1995-09-20

  A process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt or ester thereof comprises i) contacting impure clavulanic acid or an alkali metal salt thereof in an organic solvent, with an amine of formula (II) where R¹ is a group of general formula where R⁴ and R⁵ are independently hydrogen, alkyl, amino-substituted alkyl or substituted amino-substituted alkyl, and R² and R³ are independently selected from hydrogen, alkyl, amino- or hydroxy-substituted alkyl or substituted amino-substituted alkyl, and m is zero or an integer 1 to 5; ii) isolating the amine salt of clavulanic acid formed; iii) converting the thus formed salt into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.

  制备和/或纯化克拉维酸或其药学上可接受的盐或酯的工艺包括 i) 将有机溶剂中的不纯克拉维酸或其碱金属盐与式 (II) 的胺接触 其中 R¹ 为通式基团 其中 R⁴ 和 R⁵ 独立地为氢、烷基、氨基取代的烷基或取代的氨基取代的烷基，且 R² 和 R³ 独立地选自氢、烷基、氨基或羟基取代的烷基或取代的氨基取代的烷基，且 m 为零或 1 至 5 的整数； ii) 分离所形成的克拉维酸胺盐； iii) 将由此形成的盐转化为克拉维酸或其药学上可接受的盐或酯。
• Polyamine salts of clavulanic acid
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0747383A2

  公开（公告）日：1996-12-11

  A process for the preparation of clavulanic acid or its pharmaceutically acceptable salts and esters in which an amine of formula (II): is used as an intermediate to form a salt with clavulanic acid, R1, R2 and R3 being selected from various substituent atoms and groups.

  一种制备克拉维酸或其药学上可接受的盐和酯的工艺，其中式 (II)： 作为中间体与克拉维酸形成盐，R1、R2 和 R3 选自各种取代原子和基团。
• PHOTOPOLYMERIZABLE RESIN COMPOSITION AND USE THEREOF
  申请人：Nippon Steel Chemical Co., Ltd.

  公开号：EP1153935A1

  公开（公告）日：2001-11-14

  This invention relates to a photopolymerizable resin composition containing resin component (A) composed of a resin and/or a resin-forming ingredient and a photopolymerization initiator (B) wherein the component (A) comprises an addition-polymerizable compound (A1) having at least two ethylenically unsaturated groups and the photopolymerization initiator (B) comprises a diaminobenzophenone compound (B1), an N-phenylglycine compound (B2), and at least one kind of compound selected from a group of a 3,3',4,4'-tetra (alkylperoxycarbonyl) benzophenone (B3), 2-methyl-1-[4-(thiomethyl)phenyl]-2-morpholinopropan-1-one (B4), and a 1,3,5-triazine derivative (B5) containing at least one trihalomethyl group as substituent.A photopolymerizable resin composition of this invention excels in resolution, adhesion of patterns, development latitude, and curing on the surface and inside and can be used advantageously in insulating films, colored films, inks for color filters, resists for semiconductors, and insulating spacers for touch panels.

  本发明涉及一种可光聚合的树脂组合物，该树脂组合物含有由树脂和/或树脂形成成分和光聚合引发剂（B）组成的树脂组分（A），其中组分（A）包括至少具有两个乙烯基不饱和基团的可加成聚合的化合物（A1），光聚合引发剂（B）包括二氨基二苯甲酮化合物（B1）、N-苯基甘氨酸化合物（B2）和至少一种选自3,3',4,4'-四（烷基过氧羰基）化合物组的化合物、一种 N-苯基甘氨酸化合物（B2），以及至少一种选自 3,3',4,4'-四（烷基过氧羰基）二苯甲酮（B3）、2-甲基-1-[4-（硫甲基）苯基]-2-吗啉丙-1-酮（B4）和含有至少一个三卤甲基作为取代基的 1,3,5-三嗪衍生物（B5）的化合物。本发明的可光聚合树脂组合物在分辨率、图案附着力、显影宽容度以及表面和内部固化方面都有优异的表现，可以很好地用于绝缘薄膜、彩色薄膜、彩色滤光片油墨、半导体抗蚀剂和触摸屏绝缘间隔物。
• Adhesive composition, resin cured product obtained from adhesive composition, method for manufacturing semiconductor device using adhesive composition, and solid-state imaging element
  申请人：HITACHI CHEMICAL COMPANY, LTD.

  公开号：US10358580B2

  公开（公告）日：2019-07-23

  An adhesive composition comprising (a) a compound having at least two ethylenically unsaturated groups, (b) a thermal polymerization initiator, (c) a hindered phenolic compound, (d) a thioether compound and (e) a compound having a thiol group.

  一种粘合剂组合物，包括：(a) 具有至少两个乙烯不饱和基团的化合物；(b) 热聚合引发剂；(c) 受阻酚类化合物；(d) 硫醚化合物；(e) 具有硫醇基团的化合物。