(E)-4-Methyl-hex-4-enoic acid methyl ester | 97764-27-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (E)-4-Methyl-hex-4-enoic acid methyl ester
• 英文别名: Methyl 4-methylhex-4-enoate；methyl 4-methylhex-4-enoate
• CAS: 97764-27-7
• 化学式: C₈H₁₄O₂
• 分子量: 142.198
• InChiKey: URJIUPHKTWOGMR-UHFFFAOYSA-N

物化性质

• 沸点：
  149.7±9.0 °C(Predicted)
• 密度：
  0.902±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-4-Methyl-hex-4-enoic acid methyl ester 在 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 生成 4-Methylhex-4-enal
  参考文献：
  名称：

  Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials

  摘要：

  Introduction in therapy of the naturally occurring trioxane artemisinin opened a new era in malaria treatment and prompted the development of semisynthetic and synthetic derivatives characterized by the presence of the key peroxide bridge. The 1,2-dioxane ring is present in some natural endoperoxides Such as plakortin and dihydroplakortin, which are endowed with interesting antimalarial properties. Here we describe the development of a versatile stereocontrolled synthetic strategy to 1,2-dioxanes functionalized at the critical C3, C4, and C6 positions, potentially useful for the development of innovative antimalarials. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.07.137
• 作为产物：
  描述：

  methyl 4-methyl-4-nitro-5-hexenoate 在 偶氮二异丁腈 、 三正丁基氢锡 作用下， 以 苯 为溶剂， 反应 1.0h， 生成 methyl 4-methylhex-5-enoate 、 (E)-4-Methyl-hex-4-enoic acid methyl ester
  参考文献：
  名称：

  New synthetic methods. Conjugate addition of alkyl groups to electron deficient olefins with nitroalkanes as alkyl anion equivalents

  摘要：

  DOI：

  10.1021/jo00220a003

文献信息

• New synthetic methods. Conjugate addition of alkyl groups to electron deficient olefins with nitroalkanes as alkyl anion equivalents
  作者：Noboru Ono、Akio Kamimura、Hideyoshi Miyake、Isami Hamamoto、Aritsune Kaji

  DOI：10.1021/jo00220a003

  日期：1985.10
• Synthetic studies toward 1,2-dioxanes as precursors of potential endoperoxide-containing antimalarials
  作者：Sandra Gemma、Francesc Martí、Emanuele Gabellieri、Giuseppe Campiani、Ettore Novellino、Stefania Butini

  DOI：10.1016/j.tetlet.2009.07.137

  日期：2009.10

  Introduction in therapy of the naturally occurring trioxane artemisinin opened a new era in malaria treatment and prompted the development of semisynthetic and synthetic derivatives characterized by the presence of the key peroxide bridge. The 1,2-dioxane ring is present in some natural endoperoxides Such as plakortin and dihydroplakortin, which are endowed with interesting antimalarial properties. Here we describe the development of a versatile stereocontrolled synthetic strategy to 1,2-dioxanes functionalized at the critical C3, C4, and C6 positions, potentially useful for the development of innovative antimalarials. (C) 2009 Elsevier Ltd. All rights reserved.