2-ethyl-4-(4-chloro-phenyl)-thiazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-ethyl-4-(4-chloro-phenyl)-thiazole
• 英文别名: 2-Aethyl-4-(4-chlor-phenyl)-thiazol；4-(4-Chlorophenyl)-2-ethyl-1,3-thiazole
• 化学式: C₁₁H₁₀ClNS
• 分子量: 223.726
• InChiKey: CFVFCXSQSADCGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Novel piperazines, pharmaceutical compositions and methods of use thereof
  申请人：Clark B. Roger

  公开号：US20080051415A1

  公开（公告）日：2008-02-28

  Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

  本发明涉及一种新的哌嗪衍生物，其作为α7 nAChR的激动剂。同时还揭示了制药组合物，治疗炎症疾病的方法，治疗中枢神经系统疾病的方法，抑制哺乳动物细胞细胞因子释放的方法以及制备新化合物的方法。
• FUNGICIDAL N-CYCLOALKYL-CARBOXAMIDE DERIVATIVES
  申请人：Dunkel Ralf

  公开号：US20090326016A1

  公开（公告）日：2009-12-31

  The present invention relates to N-cycloalkyl-thiocarboxamide or N-cycloalkyl-N-substituted carboximidamide derivatives of formula (I) wherein A and B represent a 5-membered heterocyclyl groups, T represents an oxygen, sulphur or amino derivatives, Z 1 represents a cycloalkyl group and Z 2 and Z 3 represent various substituents, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions.

  本发明涉及公式（I）中的N-环烷基硫代甲酰胺或N-环烷基-N-取代羧酰亚胺衍生物，其中A和B代表5-成员杂环基团，T代表氧、硫或氨基衍生物，Z1代表环烷基团，Z2和Z3代表各种取代基，其制备方法，其用作杀真菌活性剂，特别是作为杀真菌组合物的形式，以及使用这些化合物或组合物控制植物病原真菌，尤其是植物的方法。
• Novel Piperazines, Pharmaceutical Compositions and Methods of Use Thereof
  申请人：Clark Roger B.

  公开号：US20120071652A1

  公开（公告）日：2012-03-22

  Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

  本发明涉及新型哌嗪衍生物，其作为α7 nAChR的激动剂。本发明还涉及制药组合物、治疗炎症性疾病的方法、治疗中枢神经系统疾病的方法、抑制哺乳动物细胞细胞因子释放的方法以及制备新型化合物的方法。
• US7943622B2
  申请人：——

  公开号：US7943622B2

  公开（公告）日：2011-05-17
• US8026195B2
  申请人：——

  公开号：US8026195B2

  公开（公告）日：2011-09-27