3-(2,6-difluorophenyl)-4-ethyl-1H-pyrazole | 500129-17-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(2,6-difluorophenyl)-4-ethyl-1H-pyrazole
• 英文别名: 5-(2,6-difluorophenyl)-4-ethyl-1H-pyrazole
• CAS: 500129-17-9
• 化学式: C₁₁H₁₀F₂N₂
• mdl: MFCD00111267
• 分子量: 208.211
• InChiKey: KTPDJTLGHWSVFU-UHFFFAOYSA-N

物化性质

• 沸点：
  338.3±42.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.181
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF
  申请人：North Shore-Long Island Jewish Health System

  公开号：EP1355921A2

  公开（公告）日：2003-10-29
• HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA
  申请人：Yuzhakov Alexander

  公开号：US20110230407A1

  公开（公告）日：2011-09-22

  Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord injury, by administering a compound or pharmaceutical composition of the invention. Useful compounds include hepatocyte growth factor/scatter factor protein, fragments, fusion polypeptides and muteins thereof, and nucleic acid and expression vectors encoding such proteins. Other useful compounds include small molecule HGF/SF agonists and mimetics.
• US7879898B1
  申请人：——

  公开号：US7879898B1

  公开（公告）日：2011-02-01
• [EN] MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF<br/>[FR] MODULATEURS DE LA PROLIFERATION CELLULAIRE ET ANGIOGENESE, LEURS PROCEDES D'UTILISATION ET D'IDENTIFICATION
  申请人：LONG ISLAND JEWISH RES INST

  公开号：WO2002002593A2

  公开（公告）日：2002-01-10

  The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
• [EN] HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES<br/>[FR] ACTIVATEURS DES VOIES DU FACTEUR DE CROISSANCE HÉPATOCYTAIRE DANS LES MALADIES DES TISSUS CONJONCTIFS FIBROTIQUES
  申请人：ANGION BIOMEDICA CORP

  公开号：WO2009064422A2

  公开（公告）日：2009-05-22

  Methods are provided for treating fibrotic connective tissue diseases such as scleroderma and conditions such as surgically-induced adhesions using compounds that activate the signaling pathways of hepatocyte growth factor.