3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]propanoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]propanoic acid
• 化学式: C₁₃H₈F₆N₂O₃
• 分子量: 354.2
• InChiKey: MAWCWRDYVZNCQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• MEDICAMENTS FOR THE TREATMENT OF OPHTHALMIC DISEASES
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP3848353A1

  公开（公告）日：2021-07-14

  Provided is a medicament for use in the treatment of a disease mediated by an increase in RBP4 or retinol supplied by RBP4 which is an ophthalmic disease. This medicament comprises a compound represented by the formula (I): wherein each symbol is as defined in the claims.

  本发明提供了一种用于治疗由 RBP4 或由 RBP4 提供的视黄醇增加介导的眼科疾病的药物。 该药物包括由式（I）代表的化合物： 其中各符号如权利要求中定义。
• Heterocyclic compound
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10544111B2

  公开（公告）日：2020-01-28

  Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.

  本发明提供了一种杂环化合物，该化合物具有优异的降低 RBP4 作用，可用作预防或治疗由 RBP4 或由 RBP4 提供的视黄醇增加介导的疾病或症状的药物。 由式(I)代表的化合物： 其中各符号如说明书中所定义，或其盐具有优异的降低 RBP4 作用，可用作预防或治疗由 RBP4 或由 RBP4 提供的视黄醇增加所介导的疾病或症状的药物。
• THE APPLICATION USING NON-COVALENT BOND BETWEEN A CUCURBITURIL DERIVATIVE AND A LIGAND
  申请人：Postech Academy-Industry- Foundation

  公开号：EP1951723B1

  公开（公告）日：2017-08-30
• EP3210973A1
  申请人：——

  公开号：EP3210973A1

  公开（公告）日：2017-08-30
• HETEROCYCLIC COMPOUND
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US20180237404A1

  公开（公告）日：2018-08-23

  Provided is a heterocyclic compound having a superior RBP4-lowering action and useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4. A compound represented by the formula (I): wherein each symbol is as defined in the Description, or a salt thereof has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of a disease or symptom mediated by an increase in RBP4 or retinol supplied by RBP4.