diethyl 2-(3-chloro-2-methylpropyl)malonate | 57498-82-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: diethyl 2-(3-chloro-2-methylpropyl)malonate
• 英文别名: Diethyl 2-(3-chloro-2-methylpropyl)propanedioate
• CAS: 57498-82-5
• 化学式: C₁₁H₁₉ClO₄
• 分子量: 250.722
• InChiKey: BXCXJZGDRAFFCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  diethyl 2-(3-chloro-2-methylpropyl)malonate 生成 3-Methyl-1,1-cyclobutandicarbonsaeure-diaethylester
  参考文献：
  名称：

  PRELOG, V.;THIX, J., HELV. CHIM. ACTA, 1982, 65, N 8, 2622-2644

  摘要：

  DOI：
• 作为产物：
  描述：

  1-溴-3-氯-2-甲基丙烷 、 丙二酸二乙酯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以53%的产率得到diethyl 2-(3-chloro-2-methylpropyl)malonate
  参考文献：
  名称：

  Effect of Conformational Preorganization of a Three-Armed Host on Anion Binding and Selectivity

  摘要：

  A set of three-armed urea-containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side-arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride nitrate-selectivity.

  DOI：

  10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v

文献信息

• Palladium‐Catalyzed Atom‐Transfer Radical Cyclization at Remote Unactivated C(sp ³ )−H Sites: Hydrogen‐Atom Transfer of Hybrid Vinyl Palladium Radical Intermediates
  作者：Maxim Ratushnyy、Marvin Parasram、Yang Wang、Vladimir Gevorgyan

  DOI：10.1002/anie.201712775

  日期：2018.3

  A novel mild, visible‐light‐induced palladium‐catalyzed hydrogen atom translocation/atom‐transfer radical cyclization (HAT/ATRC) cascade has been developed. This protocol involves a 1,5‐HAT process of previously unknown hybrid vinyl palladium radical intermediates, thus leading to iodomethyl carbo‐ and heterocyclic structures.

  一种新型温和、可见光诱导的钯催化氢原子易位/原子转移自由基环化（HAT/ATRC）级联已经开发出来。该方案涉及先前未知的杂化乙烯基钯自由基中间体的 1,5-HAT 过程，从而产生碘甲基碳环和杂环结构。
• l-2-Amino-4-methylpimelic acid: A new amino acid from Lactarius species
  作者：Shin-Ichi Hatanaka、Hitoshi Iizumi、Atsuko Tsuji、Rolf Gmelin

  DOI：10.1016/0031-9422(75)85350-7

  日期：1975.7

  Abstract A PC survey revealed the occurrence of an unusual amino acid in fruit bodies of the mushroom Lactarius quietus Fr. and a related species. This was identified as l -2-amino-4-methylpimelic acid, which has not been previously reported as a naturally occurring compound.

  摘要 一项 PC 调查揭示了蘑菇 Lactarius quietus Fr 子实体中存在一种不寻常的氨基酸。和一个相关物种。这被鉴定为 1 -2-氨基-4-甲基庚二酸，以前没有报道过它是天然存在的化合物。
• Kasanskii; Lukina, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1951, p. 47,54
  作者：Kasanskii、Lukina

  DOI：——

  日期：——
• Effect of Conformational Preorganization of a Three-Armed Host on Anion Binding and Selectivity
  作者：Frank Hettche、Philipp Reiß、Reinhard W. Hoffmann

  DOI：10.1002/1521-3765(20021104)8:21<4946::aid-chem4946>3.0.co;2-v

  日期：2002.11.4

  A set of three-armed urea-containing anion receptors was prepared. The receptors all have the same binding topology but differ in the level of conformational preorganisation with respect to the arrangement of the side-arms relative to the platform and within the side arms themselves. This is mirrored in a specific increase (x 2.5) in the binding constant for chloride and in a 12-fold increase in the chloride nitrate-selectivity.
• PRELOG, V.;THIX, J., HELV. CHIM. ACTA, 1982, 65, N 8, 2622-2644
  作者：PRELOG, V.、THIX, J.

  DOI：——

  日期：——