3-(2,3-dihydro-1H-indol-1-yl)propane-1,2-diol | 313496-07-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3-(2,3-dihydro-1H-indol-1-yl)propane-1,2-diol
• 英文别名: 3-(2,3-dihydro-1H-indol-1-yl)-1,2-propanediol；3-(2,3-dihydroindol-1-yl)propane-1,2-diol
• CAS: 313496-07-0
• 化学式: C₁₁H₁₅NO₂
• mdl: MFCD00463570
• 分子量: 193.246
• InChiKey: KMCUGWKATZWJOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.454
• 拓扑面积：
  43.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚啉 、 缩水甘油 反应 2.0h， 生成 3-(2,3-dihydro-1H-indol-1-yl)propane-1,2-diol
  参考文献：
  名称：

  Cure accelerators for anaerobic curable compositions

  摘要：

  本发明涉及用于厌氧固化组合物（如胶粘剂和密封剂）的固化促进剂。该固化促进剂是由二元醇构建的脲/尿素/硫脲（甲基）丙烯酸酯树脂，并包括结构A中所包含的单元，其中X为C1-20烷基，C2-20烯基或C7-20芳基烷基，其中任何一种均可被一个或多个氢氧基原子中断，并且这些基团中至少有一个，优选至少有两个，被选自—OH、—NH2或—SH的基团所官能化，z为1-3。

  公开号：

  US08362112B2

文献信息

• Indole derivatives as CFTR modulators
  申请人：Ruah Sara S. Hadida

  公开号：US20090131492A1

  公开（公告）日：2009-05-21

  Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物，可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜传导调节因子（“CFTR”）。本发明还涉及使用本发明的化合物治疗ABC转运蛋白介导的疾病的方法。
• Reactive resins made from renewable sources
  申请人：Henkel IP & Holding GmbH

  公开号：US10822444B2

  公开（公告）日：2020-11-03

  The invention provides reactive resins compounds and compositions made from renewable materials, such as plant and animal oils. The reactive resins compounds and compositions may include an accelerator as part of their structure and are made from renewable materials containing a variety of functional groups. The compositions provide excellent adhesion and sealing capability.

  本发明提供由植物油和动物油等可再生材料制成的活性树脂化合物和组合物。 这些反应性树脂化合物和组合物的结构中可包括一种促进剂，并由含有各种官能团的可再生材料制成。 这些组合物具有优异的粘附性和密封性。
• CURE ACCELERATORS FOR ANAEROBIC CURABLE COMPOSITIONS
  申请人：Henkel US IP LLC

  公开号：EP2424931B1

  公开（公告）日：2015-03-04
• SCREENING METHODS FOR AMYLOID BETA MODULATORS
  申请人：Slon-Usakiewicz Jacek

  公开号：US20110028719A1

  公开（公告）日：2011-02-03

  The present invention relates to methods for screening, identifying, and/or quantifying modulators of amyloid and/or aggregates, fibrils or components thereof, in particular modulators of amyloid β-peptide (Aβ) or Aβ fibrils. Aspects of the invention provide methods for screening putative modulators against an Amyloid target, in particular an Aβ target, so as to determine which modulators bind to or interact with the target, or interfere with the interaction of an indicator agent and the target. Particular aspects of the invention employ mass spectrometric methods for the screening of an Amyloid target against compound libraries, in particular mixtures of compounds or combinatorial libraries.
• ADHESIVE COMPOSITIONS
  申请人：Henkel IP & Holding GmbH

  公开号：US20200040223A1

  公开（公告）日：2020-02-06

  The present invention provides fast fixturing two part adhesive compositions which include a first part containing a (meth)acrylic component and a cure system for an epoxy resin component of the second part and a second part containing an epoxy resin component and a cure accelerator for the (meth)acrylic component of the first part.