3,5-bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)anisole | 249630-29-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 3,5-bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)anisole
• 英文别名: 7-[[3-[[(4,6-Dimethyl-2-oxochromen-7-yl)-ethylamino]methyl]-5-methoxyphenyl]methyl-ethylamino]-4,6-dimethylchromen-2-one
• CAS: 249630-29-3
• 化学式: C₃₅H₃₈N₂O₅
• 分子量: 566.697
• InChiKey: UORATWGOBDBFSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  42
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  68.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3,5-bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)anisole 在 三溴化硼 作用下， 以 二氯甲烷 为溶剂， 反应 2.0h， 以95%的产率得到3,5-Bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)phenol
  参考文献：
  名称：

  Modular Approach to the Accelerated Convergent Growth of Laser Dye-Labeled Poly(aryl ether) Dendrimers Using a Novel Hypermonomer

  摘要：

  The synthesis of novel dendrimers functionalized with laser dyes both at the periphery and at the core, along with all relevant model compounds necessary for accurate photophysical studies, is described. The utilized synthetic strategy involves a modular approach in which a variety of peripheral and core moieties can be placed an a dendritic structure bearing electrophilic peripheral groups and a nucleophilic core. Specifically, the target macromolecules required functionalization with the laser dyes coumarin 2 (periphery) and coumarin 343 (core) due to the possibility of energy transfer from the former to the latter dye. In addition, the preparation of a novel, highly soluble and reactive hypermonomer utilized in the rapid and efficient synthesis of high-generation dye-labeled dendrimers and model compounds is outlined.

  DOI：

  10.1021/jo990776m
• 作为产物：
  描述：

  3,5-二甲基苯甲醚 在 N-溴代丁二酰亚胺(NBS) 、 potassium carbonate 、 过氧化苯甲酰 作用下， 以 四氯化碳 、 乙腈 为溶剂， 反应 86.0h， 生成 3,5-bis(N-(4,6-dimethyl-7-ethylaminocoumarin)methyl)anisole
  参考文献：
  名称：

  Modular Approach to the Accelerated Convergent Growth of Laser Dye-Labeled Poly(aryl ether) Dendrimers Using a Novel Hypermonomer

  摘要：

  The synthesis of novel dendrimers functionalized with laser dyes both at the periphery and at the core, along with all relevant model compounds necessary for accurate photophysical studies, is described. The utilized synthetic strategy involves a modular approach in which a variety of peripheral and core moieties can be placed an a dendritic structure bearing electrophilic peripheral groups and a nucleophilic core. Specifically, the target macromolecules required functionalization with the laser dyes coumarin 2 (periphery) and coumarin 343 (core) due to the possibility of energy transfer from the former to the latter dye. In addition, the preparation of a novel, highly soluble and reactive hypermonomer utilized in the rapid and efficient synthesis of high-generation dye-labeled dendrimers and model compounds is outlined.

  DOI：

  10.1021/jo990776m

文献信息

• Modular Approach to the Accelerated Convergent Growth of Laser Dye-Labeled Poly(aryl ether) Dendrimers Using a Novel Hypermonomer
  作者：Sylvain L. Gilat、Alex Adronov、Jean M. J. Fréchet

  DOI：10.1021/jo990776m

  日期：1999.10.1

  The synthesis of novel dendrimers functionalized with laser dyes both at the periphery and at the core, along with all relevant model compounds necessary for accurate photophysical studies, is described. The utilized synthetic strategy involves a modular approach in which a variety of peripheral and core moieties can be placed an a dendritic structure bearing electrophilic peripheral groups and a nucleophilic core. Specifically, the target macromolecules required functionalization with the laser dyes coumarin 2 (periphery) and coumarin 343 (core) due to the possibility of energy transfer from the former to the latter dye. In addition, the preparation of a novel, highly soluble and reactive hypermonomer utilized in the rapid and efficient synthesis of high-generation dye-labeled dendrimers and model compounds is outlined.