6,8-dibromo-2-(2,6-dichlorophenyl)-3-nitro-2H-chromene

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 6,8-dibromo-2-(2,6-dichlorophenyl)-3-nitro-2H-chromene
• 化学式: C15H7Br2Cl2NO3
• 分子量: 479.9
• InChiKey: AXDNXPQTJHAYKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] NEW PI3K/AKT/MTOR INHIBITORS AND PHARMACEUTICAL USES THEREOF<br/>[FR] NOUVEAUX INHIBITEURS DE PI3K/AKT/MTOR ET LEURS UTILISATIONS PHARMACEUTIQUES
  申请人：UNIV RENNES

  公开号：WO2015044229A1

  公开（公告）日：2015-04-02

  The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

  这项发明涉及新的PI3K/AKT/mTOR抑制剂及其用于预防和/或治疗以下疾病的方法：炎症性疾病、自身免疫疾病、神经退行性疾病、癌症、移植排斥、早衰症和结节性硬化症。
• New PI3K/AKT/mTOR inhibitors and pharmaceutical uses thereof
  申请人：Université de Rennes 1

  公开号：EP2853530A1

  公开（公告）日：2015-04-01

  The invention relates to new PI3K/AKT/mTOR inhibitors of formula (I) and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

  该发明涉及公式（I）的新PI3K/AKT/mTOR抑制剂及其用于预防和/或治疗以下疾病的选定组合：炎症性疾病、自身免疫疾病、神经退行性疾病、癌症、移植排斥、以及早衰和结节性硬化等疾病。
• NEW PI3K/AKT/MTOR INHIBITORS AND PHARMACEUTICAL USES THEREOF
  申请人：UNIVERSITE DE RENNES 1

  公开号：US20160244424A1

  公开（公告）日：2016-08-25

  The invention relates to new PI3K/AKT/m TOR inhibitors and their use for the prevention and/or the treatment of a disease selected from the group consisting of: inflammatory diseases, autoimmune diseases, neurodegenerative diseases, cancers, transplant rejection, diseases characterized by a premature aging and tuberous sclerosis.

  本发明涉及新的PI3K/AKT/mTOR抑制剂及其用于预防和/或治疗以下疾病的方法：炎症性疾病、自身免疫性疾病、神经退行性疾病、癌症、移植排斥、早衰和结节性硬化症。
• Monosaccharide amine and 3-nitro-2-phenyl-2H-chromene based inhibitors of glucose kinases
  申请人：UNIVERSITY OF SOUTH CAROLINA

  公开号：US11059842B2

  公开（公告）日：2021-07-13

  Inhibitor compounds with biological activity against kinetoplastid parasites, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the target Trypanosoma cruzi glucokinase. Compounds include derivatives of 3-nitro-2-phenyl-2H-chromene, and monosaccharide amines including D-glucosamine, D-mannosamine, D-galactosamine, and D-fructosamine.

  本研究提供了对克氏原虫寄生虫具有生物活性的抑制剂化合物及其使用方法。这些化合物可用于强效抑制原生动物寄生虫中发现的关键药物靶标，例如靶标克氏锥虫葡萄糖激酶。化合物包括 3-硝基-2-苯基-2H-色烯的衍生物，以及单糖胺，包括 D-氨基葡萄糖、D-氨基甘露糖、D-半乳糖胺和 D-果糖胺。
• Non-peptidyl agents with pHSP20-like activity, and uses thereof
  申请人：von Rechenberg Moritz

  公开号：US20090136561A1

  公开（公告）日：2009-05-28

  The present invention provides compositions and methods for modulating smooth muscle cells. The present invention also provides methods of identifying small molecule candidate therapeutic agents for modulating smooth muscle.