5-Ethyl-2-(2-methylpropyl)-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Ethyl-2-(2-methylpropyl)-1,3-oxazole
• 英文别名: 5-ethyl-2-(2-methylpropyl)-1,3-oxazole
• 化学式: C₉H₁₅NO
• 分子量: 153.22
• InChiKey: UGOWIZVERAQMGT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] 6-MEMBERED URACIL ISOSTERES<br/>[FR] ISOSTÈRES D'URACILE À 6 CHAÎNONS
  申请人：CV6 THERAPEUTICS NI LTD

  公开号：WO2018098204A1

  公开（公告）日：2018-05-31

  Provided herein are dUTPase inhibitors, compositions comprising such compounds and methods of using such compounds and compositions.

  本文件提供了dUTPase抑制剂，包含此类化合物的组合物以及使用此类化合物和组合物的方法。
• Polycyclic pyridone derivative having integrase inhibitory activity
  申请人：Shionogi & Co., Ltd.

  公开号：US10011613B2

  公开（公告）日：2018-07-03

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.

  本发明涉及一种具有抗病毒作用的新型化合物，更具体地说，是一种具有艾滋病病毒整合酶抑制活性的吡啶酮衍生物，以及含有该化合物的药物，特别是抗艾滋病病毒药物。本发明的化合物对病毒，特别是艾滋病毒及其耐药菌株具有整合酶抑制活性和/或细胞增殖抑制活性。因此，本发明化合物可用于预防或治疗整合酶参与的各种疾病、病毒感染（如艾滋病）等。
• HETEROCYCLIC INHIBITORS OF MCT4
  申请人：Vettore, LLC

  公开号：EP3551625A1

  公开（公告）日：2019-10-16
• POLYCYCLIC PYRIDONE DERIVATIVE HAVING INTEGRASE INHIBITORY ACTIVITY
  申请人：Shionogi & Co., Ltd.

  公开号：US20170226128A1

  公开（公告）日：2017-08-10

  The present invention relates to a novel compound having an antiviral effect, more specifically, a pyridone derivative having HIV integrase inhibitory activity, and a medicament containing the same, in particular, an anti-HIV agent. The compound of the present invention has integrase inhibitory activity and/or cell proliferation inhibitory activity against viruses, in particular, HIV and drug-resistant strains thereof. Thus, the compound is useful in preventing or treating various diseases, viral infections (for example, AIDS), and the like in which integrase participates.
• [EN] HETEROCYCLIC INHIBITORS OF MCT4<br/>[FR] INHIBITEURS HÉTÉROCYCLIQUES DE MCT4
  申请人：VETTORE LLC

  公开号：WO2018111904A1

  公开（公告）日：2018-06-21

  Disclosed herein are compounds and compositions useful in the treatment of MCT4 mediated diseases, such as proliferative and inflammatory diseases, having the structure of Formula (I). Methods of inhibition MCT4 activity in a human or animal subject are also provided.