5-chloro-2-(4-methoxyphenyl)oxazole-4-carbaldehyde | 1268161-53-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-chloro-2-(4-methoxyphenyl)oxazole-4-carbaldehyde
• 英文别名: 5-Chloro-2-(4-methoxyphenyl)-1,3-oxazole-4-carbaldehyde；5-chloro-2-(4-methoxyphenyl)-1,3-oxazole-4-carbaldehyde
• CAS: 1268161-53-0
• 化学式: C₁₁H₈ClNO₃
• 分子量: 237.642
• InChiKey: CNESBGDJQZMMAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  52.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对甲氧基苯甲酰氯 在 三光气 、 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 9.0h， 生成 5-chloro-2-(4-methoxyphenyl)oxazole-4-carbaldehyde
  参考文献：
  名称：

  A Convenient Method for Synthesis of 5-Chloro-2-aryloxazole-4-carbaldehyde with Vilsmeier Reagent

  摘要：

  A convenient method for synthesis of 5-chloro-2-aryloxazole-4-carbaldehyde 3 in moderate to good yields had been developed via the Vilsmeier reaction of readily available N-arylglycine 2 at 100 degrees C, provided a novel route for the construction of nitrogen heterocycles. A series of these compounds were synthesized by this method and optimization of conditions was performed.

  DOI：

  10.3987/com-10-12090

文献信息

• A Convenient Method for Synthesis of 5-Chloro-2-aryloxazole-4-carbaldehyde with Vilsmeier Reagent
  作者：Weike Su、Can Jin、Jun Chen

  DOI：10.3987/com-10-12090

  日期：——

  A convenient method for synthesis of 5-chloro-2-aryloxazole-4-carbaldehyde 3 in moderate to good yields had been developed via the Vilsmeier reaction of readily available N-arylglycine 2 at 100 degrees C, provided a novel route for the construction of nitrogen heterocycles. A series of these compounds were synthesized by this method and optimization of conditions was performed.