(2S,3S)-3-t-butoxycarbonylamino-2-hydroxy-5-methylhexanol | 96387-10-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,3S)-3-t-butoxycarbonylamino-2-hydroxy-5-methylhexanol
• 英文别名: tert-butyl N-[(2S,3S)-1,2-dihydroxy-5-methylhexan-3-yl]carbamate
• CAS: 96387-10-9
• 化学式: C₁₂H₂₅NO₄
• 分子量: 247.335
• InChiKey: JEKLTFZZNJKROP-VHSXEESVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  78.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2S,3S)-3-t-butoxycarbonylamino-2-hydroxy-5-methylhexanol 在 4-二甲氨基吡啶 、 偶氮二甲酸二异丙酯 、 甲基磺酰氯 、 间氯过氧苯甲酸 、 三苯基膦 作用下， 以 甲醇 、 二氯甲烷 、 氯仿 为溶剂， 反应 1.0h， 生成 (3S,E)-3-(tert-butoxycarbonylamino)-5-methyl-1-methylsulfonyl-1-hexene
  参考文献：
  名称：

  Enantiodivergent, Catalytic Asymmetric Synthesis of γ-Amino Vinyl Sulfones

  摘要：

  A set of diversely substituted N-Boc-gamma-amino vinyl sulfones has been prepared by a four-step procedure from readily available, highly enantiopure anti-N-Boc-3-amino-1,2-alkanediols. This new route, which does not depend on the accessibility of alpha-amino acids as starting materials, is noteworthy for its efficiency, for its generality, and for the fact that both enantiomers of a given gamma-amino vinyl sulfone can be obtained with equal ease.

  DOI：

  10.1021/jo0268456
• 作为产物：
  描述：

  (2R,3R)-2,3-epoxy-5-methyl-1-hexanol 在 palladium on activated charcoal Ti(N3)2(OiPr)2 、 氢气 作用下， 以 乙酸乙酯 、 苯 为溶剂， 生成 (2S,3S)-3-t-butoxycarbonylamino-2-hydroxy-5-methylhexanol
  参考文献：
  名称：

  Enantiodivergent, Catalytic Asymmetric Synthesis of γ-Amino Vinyl Sulfones

  摘要：

  A set of diversely substituted N-Boc-gamma-amino vinyl sulfones has been prepared by a four-step procedure from readily available, highly enantiopure anti-N-Boc-3-amino-1,2-alkanediols. This new route, which does not depend on the accessibility of alpha-amino acids as starting materials, is noteworthy for its efficiency, for its generality, and for the fact that both enantiomers of a given gamma-amino vinyl sulfone can be obtained with equal ease.

  DOI：

  10.1021/jo0268456

文献信息

• Hypotensive peptides and their use
  申请人：Sankyo Company Limited

  公开号：US04548926A1

  公开（公告）日：1985-10-22

  Oligopeptides of formula (I) ##STR1## (wherein R.sup.1 CO-- is an acyl group. But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity.

  式(I)的寡肽##STR1##(其中R.sup.1 CO--是酰基。但是是异丁基或仲丁基，X是各种有机基团)及其盐和酯具有有价值的肾素抑制活性。
• New hypotensive peptides, their preparation and their use
  申请人：SANKYO COMPANY LIMITED

  公开号：EP0128762A2

  公开（公告）日：1984-12-19

  Oligopeptides of formula (I) (wherein R1 CO- is an acyl group, But is an isobutyl or sec-butyl group and X is a variety of organic groups) and salts and esters thereof have valuable renin inhibitory activity and are prepared by conventional polypeptide synthesis.

  式 (I) 的寡肽（其中 R1 CO- 是酰基，But 是异丁基或仲丁基，X 是各种有机基团 (其中 R1 CO- 是酰基，But 是异丁基或仲丁基，X 是各种有机基团）及其盐和酯具有宝贵的肾素抑制活性，可通过常规多肽合成法制备。
• US4548926A
  申请人：——

  公开号：US4548926A

  公开（公告）日：1985-10-22