¹⁸F-(S)-N-[(3R)-4-fluoro-3-hydroxybutyl]-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin | 1438898-99-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ¹⁸F-(S)-N-[(3R)-4-fluoro-3-hydroxybutyl]-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin
• 英文别名: 1-((R)-4-fluoro-3-hydroxybutyl)-5-(((S)-2-(methoxymethyl)pyrrolidin-1-yl)sulfonyl)indoline-2,3-dione；1-[(3R)-4-(18F)fluoranyl-3-hydroxybutyl]-5-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
• CAS: 1438898-99-7
• 化学式: C₁₈H₂₃FN₂O₆S
• 分子量: 413.456
• InChiKey: APKUVGMUIXJJAR-KVWUMBDGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  5-[2-(methoxymethyl)pyrrolidin-1-yl]sulfonyl-1-[2-(oxiran-2-yl)ethyl]indole-2,3-dione 在 C₈₀H₁₀₇Co₂⁽¹⁸⁾FN₄O₁₀S 作用下， 以 乙腈 为溶剂， 反应 0.33h， 生成 ¹⁸F-(S)-N-[(3R)-4-fluoro-3-hydroxybutyl]-5-[1-(2-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin
  参考文献：
  名称：

  Enantioselective Radiosynthesis of Positron Emission Tomography (PET) Tracers Containing [¹⁸F]Fluorohydrins

  摘要：

  Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [F-18](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. We demonstrate the utility of the method by preparing single enantiomer experimental and clinically validated PET tracers that contain base-sensitive functional groups, epimerizable stereocenters, and nitrogen-rich motifs. Unlike the conventional radiosyntheses of these targets with [F-18]KF, labeling with (salen)CoF is possible in the last step and under exceptionally mild conditions. These results constitute a rare example of a nucleophilic radiofluorination using a transition metal fluoride and highlight the potential of such reagents to enhance traditional methods for labeling aliphatic hydrocarbons.

  DOI：

  10.1021/ja5025645

文献信息

• Synthesis, ¹⁸F-Radiolabeling, and in Vivo Biodistribution Studies of <i>N</i>-Fluorohydroxybutyl Isatin Sulfonamides using Positron Emission Tomography
  作者：Panupun Limpachayaporn、Stefan Wagner、Klaus Kopka、Sven Hermann、Michael Schäfers、Günter Haufe

  DOI：10.1021/jm400257a

  日期：2013.6.13

  respectively), which makes them appropriate PET radiotracer candidates. Therefore, N-(4-[18F]fluoro-3(R)-hydroxybutyl)- and N-(3(S)-[18F]fluoro-4-hydroxybutyl)-5-[1-(2(S)-(methoxymethyl)pyrrolidinyl)sulfonyl]isatin were synthesized in 140 min with 24% and 10% overall radiochemical yields and specific activities of 10–127 GBq/μmol using [18F]fluoride in the presence of Kryptofix and subsequent acidic hydrolysis

  caspases-3和-7效应子在程序化的I型细胞死亡（细胞凋亡）中起着核心作用。使用正电子发射断层扫描（PET）通过跟踪执行胱天蛋白酶的活性进行的分子成像可能允许检测早期发作以及对细胞凋亡失调引起的各种疾病进行治疗监测。在此，通过用氟化物使环硫酸盐开环，制备了四种新的基于氟化的非对映体和对映体纯和对映体纯的异磺酰胺磺胺类强效和选择性caspase-3和-7抑制剂。所有的氟代醇都表现出出色的体外亲和力（对于caspase-3和-7的IC 50分别高达11.8和0.951 nM），这使其成为合适的PET放射性示踪剂。因此，N-（4- [ 18 F] fluoro-3（R）-N-（3（S）-[ 18 F]氟-4-羟基丁基）-5- [1-（2（S）-（甲氧基甲基）吡咯烷基）磺酰基] isatin的合成在140分钟内完成，在存在Kryptofix并随后进行酸性水解的情况下，使用[ 18 F]氟化物
• Enantioselective Radiosynthesis of Positron Emission Tomography (PET) Tracers Containing [¹⁸F]Fluorohydrins
  作者：Thomas J. A. Graham、R. Frederick Lambert、Karl Ploessl、Hank F. Kung、Abigail G. Doyle

  DOI：10.1021/ja5025645

  日期：2014.4.9

  Herein, we describe an operationally straightforward radiosynthesis of a chiral transition metal fluoride catalyst, [F-18](salen)CoF, and its use for late-stage enantioselective aliphatic radiofluorination. We demonstrate the utility of the method by preparing single enantiomer experimental and clinically validated PET tracers that contain base-sensitive functional groups, epimerizable stereocenters, and nitrogen-rich motifs. Unlike the conventional radiosyntheses of these targets with [F-18]KF, labeling with (salen)CoF is possible in the last step and under exceptionally mild conditions. These results constitute a rare example of a nucleophilic radiofluorination using a transition metal fluoride and highlight the potential of such reagents to enhance traditional methods for labeling aliphatic hydrocarbons.