4-amino-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]butaneamide | 61059-60-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-amino-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]butaneamide
• 英文别名: 4-amino-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]butanamide
• CAS: 61059-60-7
• 化学式: C₁₄H₁₉N₃O₂
• 分子量: 261.324
• InChiKey: WWOBEZLVHPIJHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  91.1
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 4-amino-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]butaneamide
  参考文献：
  名称：

  Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders

  摘要：

  提供一种化合物，其化学式为NH2CH2CH2CH2C(O)N—R（I），其中R是能够穿过血脑屏障的基团，可以作为自由化合物存在的有血清素、多巴胺、血脑屏障（BBB）肽、膜转位蛋白、TAT肽、激肽、β-内啡肽、波美斯因、降钙素、胆囊收缩素、镇痛肽、镇痛肽、胰岛素、胃泌素、P物质、神经肽、胰高血糖素、分泌素、生长抑素、运动素、加压素、催产素、催乳素、促甲状腺激素、血管紧张素、加拉宁、神经肽Y、促甲状腺释放激素、促性腺激素释放激素、生长激素释放激素、黄体生成素、血管活性肠肽、转铁蛋白、葡萄糖胺、氨基糖苷、乳酰胺、亮氨酸、色氨酸、谷氨酸和氨基胆碱。

  公开号：

  US20060058219A1

文献信息

• Derivates Based on Hyaluronic Acid, Capable of Forming Hydrogels, Method of Preparation Thereof, Hydrogels Based on Said Derivatives, Method of Preparation Thereof and Use
  申请人：Contipro Biotech s.r.o.

  公开号：US20150000561A1

  公开（公告）日：2015-01-01

  The invention relates to a new hyaluronan derivative according to the general formula (I), the method of preparation thereof, a hydrogel based on the new derivative, method of preparation of the hydrogel and the use of the hydrogel in tissue engineering, cosmetics, medicine or regenerative medicine, especially in the form of scaffolds for the treatment of articular cartilage or bone tissue defects.

  该发明涉及一种新的透明质酸衍生物，其通式为(I)，其制备方法，基于该新衍生物的水凝胶，水凝胶的制备方法以及水凝胶在组织工程、化妆品、医学或再生医学中的应用，尤其是作为治疗关节软骨或骨组织缺陷的支架的形式。
• DERIVATES BASED ON HYALURONIC ACID, CAPABLE OF FORMING HYDROGELS, METHOD OF PREPARATION THEREOF, HYDROGELS BASED ON SAID DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE
  申请人：Contipro Biotech s.r.o.

  公开号：EP2820051A1

  公开（公告）日：2015-01-07
• US9492586B2
  申请人：——

  公开号：US9492586B2

  公开（公告）日：2016-11-15
• [EN] DERIVATES BASED ON HYALURONIC ACID, CAPABLE OF FORMING HYDROGELS, METHOD OF PREPARATION THEREOF, HYDROGELS BASED ON SAID DERIVATIVES, METHOD OF PREPARATION THEREOF AND USE<br/>[FR] DÉRIVÉS À BASE D'ACIDE HYALURONIQUE, SUSCEPTIBLES DE FORMER DES HYDROGELS, LEUR PROCÉDÉ DE PRÉPARATION, HYDROGELS À BASE DESDITS DÉRIVÉS, LEUR PROCÉDÉ DE PRÉPARATION ET UTILISATION
  申请人：CONTIPRO BIOTECH SRO

  公开号：WO2013127374A1

  公开（公告）日：2013-09-06

  The invention relates to a new hyaluronan derivative according to the general formula (I), the method of preparation thereof, a hydrogel based on the new derivative, method of preparation of the hydrogel and the use of the hydrogel in tissue engineering, cosmetics, medicine or regenerative medicine, especially in the form of scaffolds for the tratment of articular cartilage or bone tissue defects.
• Aminobutyramide conjugate and a pharmaceutical composition for treatment of neuronal disorders
  申请人：Miller C.G. Landon

  公开号：US20060058219A1

  公开（公告）日：2006-03-16

  A compound is provided that has the formula NH 2 CH 2 CH 2 CH 2 C(O)N—R   (I) where R is a moiety capable of crossing the blood brain barrier and is as a free compound serotonin, dopamine blood brain barrier (BBB) peptide, membrane translocating protein, TAT peptides, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidetransferrin, glucosylamnine, amino saccharin, lactylamine, leucine, tryptophan, glutamate and amino cholines.

  提供一种化合物，其化学式为NH2CH2CH2CH2C(O)N—R（I），其中R是能够穿过血脑屏障的基团，可以作为自由化合物存在的有血清素、多巴胺、血脑屏障（BBB）肽、膜转位蛋白、TAT肽、激肽、β-内啡肽、波美斯因、降钙素、胆囊收缩素、镇痛肽、镇痛肽、胰岛素、胃泌素、P物质、神经肽、胰高血糖素、分泌素、生长抑素、运动素、加压素、催产素、催乳素、促甲状腺激素、血管紧张素、加拉宁、神经肽Y、促甲状腺释放激素、促性腺激素释放激素、生长激素释放激素、黄体生成素、血管活性肠肽、转铁蛋白、葡萄糖胺、氨基糖苷、乳酰胺、亮氨酸、色氨酸、谷氨酸和氨基胆碱。