(2R)-1-(5-methylpyrazol-1-yl)propan-2-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: (2R)-1-(5-methylpyrazol-1-yl)propan-2-ol
• 化学式: C₇H₁₂N₂O
• 分子量: 140.18
• InChiKey: WFCXEGRSNWJFJC-SSDOTTSWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• SEPARATION MATERIAL COMPRISING PHOSPHORYL CHOLINE DERIVATIVES
  申请人：Pentracor GmbH

  公开号：US20170120163A1

  公开（公告）日：2017-05-04

  The present invention provides phosphoryl choline derivatives of general formula (I), which are suitable to be immobilized on a solid support to provide a separation material of general formula (II), which bind with both high affinity and high specificity to a protein, more specifically to C-reactive protein and anti-phosphoryl choline antibodies. Said separation materials are particularly useful in the extracorporeal removal of C-reactive protein and anti-phosphoryl choline antibodies from a biological fluid of a patient for prophylaxis and/or treatment of immune dysfunctions and cardiovascular diseases. Also provided is a column that comprises the separation material of general formula (II), as well as a device containing the column. Formula (I), wherein variable X is selected from: —SH, —NHR 3 , —C═CH, —CH═CH 2 , —N 3 and —CHO; the other variables are as defined in the claims: Formula (II), wherein variable “A” represents a solid support. “A” as well as the other variables are defined in detail in the claims.