5-[[3-(4-Methoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[[3-(4-Methoxyphenyl)-1-phenylpyrazol-4-yl]methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione
• 化学式: C₂₁H₁₆N₄O₃S
• 分子量: 404.4
• InChiKey: QQKNAMQONXLIKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  117
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Prostaglandin E synthase inhibitors and methods for utilizing the same
  申请人：University of Kentucky Research Foundation

  公开号：US11325901B2

  公开（公告）日：2022-05-10

  Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.

  本研究提供了可抑制微粒体前列腺素 E 合酶-1（mPGES-1）的化合物和组合物。这些化合物和组合物可以减轻受试者的炎症，如炎症性疾病引起的炎症或其症状。还提供了包含该化合物的药物组合物。此外，还提供了减轻炎症和/或抑制 mPGES-1 的方法。这些方法可包括向受试者施用有效量的组合物。
• Prostaglandin E Synthase Inhibitors and Methods for Utilizing the Same
  申请人：University of Kentucky Research Foundation

  公开号：US20200231583A1

  公开（公告）日：2020-07-23

  Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.