(3aR,13bR)-2,3,3a,4,8,13-hexahydro-7H-cyclopenta[1,8a]indolizino[8,7-b]indol-5(1H)-one | 1253404-39-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: (3aR,13bR)-2,3,3a,4,8,13-hexahydro-7H-cyclopenta[1,8a]indolizino[8,7-b]indol-5(1H)-one
• 英文别名: (2R,6R)-9,19-diazapentacyclo[10.7.0.02,6.02,9.013,18]nonadeca-1(12),13,15,17-tetraen-8-one
• CAS: 1253404-39-5
• 化学式: C₁₇H₁₈N₂O
• 分子量: 266.343
• InChiKey: ZMEAYPFXPUTPHJ-PIGZYNQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  36.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  色胺 、 (2-oxocyclopent)acetic acid 在 (S)-(+)-3,3′-双(3,5-双(三氟甲基)苯基)-1,1′-联萘-2,2′-二基磷酸氢酯 作用下， 以 甲苯 为溶剂， 反应 48.0h， 生成 2,3,3a,4,8,13-hexahydro-7H-cyclopenta[1,8a]indolizino[8,7-b]indol-5(1H)-one 、 (3aR,13bR)-2,3,3a,4,8,13-hexahydro-7H-cyclopenta[1,8a]indolizino[8,7-b]indol-5(1H)-one
  参考文献：
  名称：

  Direct Enantioselective Brønsted Acid Catalyzed N-Acyliminium Cyclization Cascades of Tryptamines and Ketoacids

  摘要：

  A direct enantio- and diastereoselective N-acyliminium cyclization cascade through chiral phosphoric acid catalyzed condensation of tryptamines with gamma- and delta-ketoacid derivatives to provide architecturally complex heterocycles has been developed. The reaction is technically simple to perform, atom-efficient, and broad in scope. Employing 10 mol % of (R)-BINOL derived chiral phosphoric acids in refluxing toluene allowed the polycyclic product materials to be generated in good yields (53-99%) and moderate to high enantioselectivities (68-98% ee).

  DOI：

  10.1021/ol101651t

文献信息

• Direct Enantioselective Brønsted Acid Catalyzed <i>N</i>-Acyliminium Cyclization Cascades of Tryptamines and Ketoacids
  作者：Chloe A. Holloway、Michael E. Muratore、R. lan Storer、Darren J. Dixon

  DOI：10.1021/ol101651t

  日期：2010.11.5

  A direct enantio- and diastereoselective N-acyliminium cyclization cascade through chiral phosphoric acid catalyzed condensation of tryptamines with gamma- and delta-ketoacid derivatives to provide architecturally complex heterocycles has been developed. The reaction is technically simple to perform, atom-efficient, and broad in scope. Employing 10 mol % of (R)-BINOL derived chiral phosphoric acids in refluxing toluene allowed the polycyclic product materials to be generated in good yields (53-99%) and moderate to high enantioselectivities (68-98% ee).