1-Butan-2-yl-4-propan-2-yltriazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-Butan-2-yl-4-propan-2-yltriazole
• 英文别名: 1-butan-2-yl-4-propan-2-yltriazole
• 化学式: C₉H₁₇N₃
• 分子量: 167.25
• InChiKey: JEBHTWDVJNEQEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• COMPOUNDS AND THEIR USES AS MIF INHIBITORS
  申请人：Nanjing Immunophage BioTech Co., Ltd.

  公开号：US20210403484A1

  公开（公告）日：2021-12-30

  The present invention provides compounds of Formula I which can be used as macrophage migration inhibitory factor (MIF) inhibitors; methods for the production of the compounds of the invention; pharmaceutical compositions comprising the compounds of the invention; as well as uses and methods for treating a disease mediated by MIF by administering the compounds of the invention.

  本发明提供了一种可以用作巨噬细胞迁移抑制因子（MIF）抑制剂的化合物I的公式；本发明化合物的制备方法；包括本发明化合物的药物组合物；以及通过给予本发明化合物来治疗由MIF介导的疾病的用途和方法。
• Block co-poly(metal organic nanostructures) (BCPMONs) and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10793683B2

  公开（公告）日：2020-10-06

  The present disclosure provides (block co-polymer)-(metal organic framework) conjugates (BCPMOFs), such as (block co-polymer)-(metal organic nanostructure) conjugates (BCPMONs), and thermoplastic elastomers, gels, and compositions thereof. Exemplary BCPMONs include (block co-polymer)-(metal organic cage) conjugates (BCPMOCs), (block co-polymer)-(metal organic paddlewheel) conjugates, and (block co-polymer)-(metal organic square) conjugates, such as BCPMONs of Formula (A), (B), or (C). Also described herein are macromonomers for preparing the BCPMONs; thermoplastic elastomers, gels, and compositions involving the BCPMONs; methods of preparing the BCPMONs, thermoplastic elastomers, gels, and compositions; and methods of using the BCPMONs, thermoplastic elastomers, gels, and compositions.

  本公开提供了（嵌段共聚物）-（金属有机框架）共轭物（BCPMOFs），例如（嵌段共聚物）-（金属有机纳米结构）共轭物（BCPMONs），以及热塑性弹性体、凝胶及其组合物。示例性 BCPMON 包括（嵌段共聚物）-（金属有机笼）共轭物（BCPMOC）、（嵌段共聚物）-（金属有机桨轮）共轭物和（嵌段共聚物）-（金属有机方形）共轭物，如式（A）、（B）或（C）的 BCPMON。本文还描述了用于制备 BCPMONs 的大单体；涉及 BCPMONs 的热塑性弹性体、凝胶和组合物；制备 BCPMONs、热塑性弹性体、凝胶和组合物的方法；以及使用 BCPMONs、热塑性弹性体、凝胶和组合物的方法。
• MODULATORS OF SOCE, COMPOSITIONS, AND USES THEREOF
  申请人：Università degli Studi del Piemonte Orientale " Amedeo Avogado"

  公开号：US20190300509A1

  公开（公告）日：2019-10-03

  Compounds of Formula (I) able to modulate Store Operated Calcium Entry (SOCE). The disclosure also relates to the use of compounds of formula (I) for treatment of pathological conditions in which SOCE modulation might be beneficial, such as neglecting disorders linked to loss- or gain-of-function STIM1/Orai1 mutations, allergic disorders, pain, inflammatory diseases, autoimmune diseases or disorders, cancer and other proliferative diseases, neurodegenerative disorders, myelodysplastic syndromes, haematological diseases, cardiovascular diseases, degenerative diseases of the musculoskeletal system, liver diseases and disorders, kidney diseases, type I diabetes, graft rejection, graft-versus-host disease, allogeneic or xenogeneic transplantation, thyroiditis and viral infections.
• ANTI-CD117 ANTIBODY-DRUG CONJUGATES AND USES THEREOF
  申请人：Magenta Therapeutics, Inc.

  公开号：US20220175944A1

  公开（公告）日：2022-06-09

  Anti-CD117 antibody-drug conjugates (ADCs) comprising pyrrolobenzodiazepine are provided, as well as compositions and methods of using the same. The compositions and methods provided herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure. Methods and compositions for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, are provided.