ethyl 3-(2-methoxy-2-oxoethyl)-1,3-dimethyl-2-oxoindoline-5-carboxylate | 1513812-96-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: ethyl 3-(2-methoxy-2-oxoethyl)-1,3-dimethyl-2-oxoindoline-5-carboxylate
• 英文别名: Ethyl 3-(2-methoxy-2-oxoethyl)-1,3-dimethyl-2-oxoindole-5-carboxylate；ethyl 3-(2-methoxy-2-oxoethyl)-1,3-dimethyl-2-oxoindole-5-carboxylate
• CAS: 1513812-96-8
• 化学式: C₁₆H₁₉NO₅
• 分子量: 305.331
• InChiKey: ODHOHFXYDJUOLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  肼基甲酸甲酯 、 ethyl 4-[methyl(2-methyl-1-oxoprop-2-enyl)amino]benzoate 在 叔丁基过氧化氢 、 iron(II) chloride tetrahydrate 作用下， 以 水 、 乙腈 为溶剂， 反应 6.0h， 以57%的产率得到ethyl 3-(2-methoxy-2-oxoethyl)-1,3-dimethyl-2-oxoindoline-5-carboxylate
  参考文献：
  名称：

  Iron-Catalyzed Arylalkoxycarbonylation of N-Aryl Acrylamides with Carbazates

  摘要：

  A novel arylalkoxycarbonylation of N-aryl acrylamides with carbazates leading to alkoxycarbonylated oxindoles has been developed. The reported reactions employ economical and environmentally benign FeCl2 center dot 4H(2)O as a catalyst and easily accessible and safe carbazates as alkoxycarbonyl radical precursors.

  DOI：

  10.1021/jo402529r

文献信息

• Iron-Catalyzed Arylalkoxycarbonylation of <i>N</i>-Aryl Acrylamides with Carbazates
  作者：Xiangsheng Xu、Yucai Tang、Xiaoqing Li、Guo Hong、Mingwu Fang、Xiaohua Du

  DOI：10.1021/jo402529r

  日期：2014.1.3

  A novel arylalkoxycarbonylation of N-aryl acrylamides with carbazates leading to alkoxycarbonylated oxindoles has been developed. The reported reactions employ economical and environmentally benign FeCl2 center dot 4H(2)O as a catalyst and easily accessible and safe carbazates as alkoxycarbonyl radical precursors.
• Synthesis of oxindole-3-acetates through iron-catalyzed oxidative arylalkoxycarbonylation of activated alkenes
  作者：Gao Wang、Shan Wang、Jian Wang、Shan-Yong Chen、Xiao-Qi Yu

  DOI：10.1016/j.tet.2014.03.062

  日期：2014.5

  An iron-catalyzed alkoxycarbonylation/cyclization reaction of N-arylacrylamides with carbazates has been developed. This new alkene difunctionalization reaction provides an efficient and straightforward method to obtain various ester-containing oxindoles. (C) 2014 Elsevier Ltd. All rights reserved.