7-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-2-oxo-2H-chromene-3-carboxylic acid methyl ester | 616200-86-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-2-oxo-2H-chromene-3-carboxylic acid methyl ester
• 英文别名: Methyl 7-[2-(5-ethylpyridin-2-yl)ethoxy]-2-oxochromene-3-carboxylate
• CAS: 616200-86-3
• 化学式: C₂₀H₁₉NO₅
• 分子量: 353.375
• InChiKey: SRMWMTKVMZFXNV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-2-oxo-2H-chromene-3-carboxylic acid methyl ester 在 palladium on activated charcoal 氢气 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 7-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-2-oxo-chroman-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative

  摘要：

  A series of benzopyran derivatives was synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 6 and 11 exhibited more potent insulin-sensitizing activity than rosiglitazone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00734-0
• 作为产物：
  描述：

  5-乙基-2-吡啶乙醇 、 7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 7-[2-(5-Ethyl-pyridin-2-yl)-ethoxy]-2-oxo-2H-chromene-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative

  摘要：

  A series of benzopyran derivatives was synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 6 and 11 exhibited more potent insulin-sensitizing activity than rosiglitazone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00734-0