2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-[(4-methyl-5-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]-N-{4-[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}acetamide
• 英文别名: N-[4-(1-adamantyl)phenyl]-2-[(4-methyl-5-phenyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
• 化学式: C₂₇H₃₀N₄OS
• 分子量: 458.6
• InChiKey: UGGGKCFAYLDSOP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  85.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• TEAD transcription factor autopalmitoylation inhibitors
  申请人：The General Hospital Corporation

  公开号：US10696642B2

  公开（公告）日：2020-06-30

  The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.

  本公开的化合物及其组合物和使用方法。这些化合物抑制 TEAD 转录因子的活性，可用于治疗与 TEAD 转录因子活性有关的疾病，包括癌症和其他疾病。
• TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS
  申请人：The General Hospital Corporation

  公开号：EP3353156B1

  公开（公告）日：2021-11-03
• [EN] TEAD TRANSCRIPTION FACTOR AUTOPALMITOYLATION INHIBITORS<br/>[FR] INHIBITEURS DE L'AUTOPALMITOYLATION DU FACTEUR DE TRANSCRIPTION TEAD
  申请人：MASSACHUSETTS GEN HOSPITAL

  公开号：WO2017053706A1

  公开（公告）日：2017-03-30

  The present disclosure compounds, as well as their compositions and methods of use. The compounds inhibit the activity of the TEAD transcription factor, and are useful in the treatment of diseases related to the activity of TEAD transcription factor including, e.g., cancer and other diseases.