N-[[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-yl-4-prop-2-enoxybenzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[[3-(3,4-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl]-N-propan-2-yl-4-prop-2-enoxybenzamide
• 化学式: C₂₄H₂₇N₃O₅
• 分子量: 437.5
• InChiKey: RFKHIKXGSFYNMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  86.9
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• NITROGEN HETEROCYCLE DERIVATIVES AS PROTEASOME MODULATORS
  申请人：VILLOUTREIX Bruno

  公开号：US20110257176A1

  公开（公告）日：2011-10-20

  A method for treating and/or ameliorating and/or preventing a disease or a disorder, the method comprising administering to an individual in need thereof at least one nitrogen heterocycle derivative of formula (I): The at least one nitrogen heterocycle derivative may also be used as a proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.

  一种治疗、改善和/或预防疾病或障碍的方法，该方法包括向需要此类治疗的个体施用至少一种公式（I）的氮杂环衍生物。该至少一种氮杂环衍生物也可用作蛋白酶体活性调节剂，用于制造预防和/或治疗由蛋白酶体活性介导的疾病状态的制药组合物。
• [EN] NITROGEN HETEROCYCLE DERIVATIVES AS PROTEASOME MODULATORS<br/>[FR] DÉRIVÉS HÉTÉROCYCLIQUES DE L'AZOTE SOUS LA FORME DE MODULATEURS DU PROTÉASOME
  申请人：INST NAT SANTE RECH MED

  公开号：WO2010001365A1

  公开（公告）日：2010-01-07

  The instant invention relates to the use of at least one nitrogen heterocycle derivative of formula (I): as proteasome activity modulator in the manufacture of a pharmaceutical composition intended to prevent and/or treat a disease condition mediated by the proteasome activity.