1-phenyl-3-thiophen-2-yl-1H-pyrazole-4-carboxylic acid pyridin-3-ylamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-phenyl-3-thiophen-2-yl-1H-pyrazole-4-carboxylic acid pyridin-3-ylamide
• 英文别名: 1-phenyl-N-(pyridin-3-yl)-3-(thiophen-2-yl)-1H-pyrazole-4-carboxamide；1-phenyl-N-pyridin-3-yl-3-thiophen-2-ylpyrazole-4-carboxamide
• 化学式: C₁₉H₁₄N₄OS
• 分子量: 346.412
• InChiKey: XBEBONAQLXUAGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  88
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Pyrazole Compounds for Controlling Invertebrate Pests
  申请人：Gross Steffen

  公开号：US20110059973A1

  公开（公告）日：2011-03-10

  The present invention relates to novel pyrazole compounds of the formulae I and II, to their salts and their N-oxides which can be used for combating or controlling invertebrate pests, in particular arthropod pests. The invention also relates to a method for controlling invertebrate pests by using these compounds. The present invention also relates to seed and to an agricultural and veterinary composition comprising said compounds. wherein A is a pyrazole radical of the formulae A1, A2 or A3 # denotes the binding site to the remainder of formulae I or II; X 1 is S, O or NR 1a ; X 2 is OR 2a , NR 2b R 2c , S(O) m R 2d ; X 3 is a lone pair or oxygen; R 1 , R 2 and R 3 are, inter alia, hydrogen, and wherein R 41 , R 42 , R 43 , R 51 , R 52 , R 53 , R 61 , R 62 , R 63 , are as defined in claim 1.

  本发明涉及式I和式II的新型吡唑化合物，以及它们的盐和N-氧化物，可用于防治或控制无脊椎动物害虫，尤其是节肢动物害虫。本发明还涉及一种使用这些化合物控制无脊椎动物害虫的方法。本发明还涉及种子以及包括所述化合物的农业和兽医组合物。其中，A是式A1、A2或A3的吡唑基团；#表示与式I或II的其余部分的结合位点；X1是S、O或NR1a；X2是OR2a、NR2bR2c、S(O)mR2d；X3是孤对电子或氧；R1、R2和R3是氢等；R41、R42、R43、R51、R52、R53、R61、R62和R63如权利要求1所定义。
• PYRAZOLE COMPOUNDS FOR CONTROLLING INVERTEBRATE PESTS
  申请人：BASF SE

  公开号：EP2197280A2

  公开（公告）日：2010-06-23
• US8642597B2
  申请人：——

  公开号：US8642597B2

  公开（公告）日：2014-02-04
• US9204647B2
  申请人：——

  公开号：US9204647B2

  公开（公告）日：2015-12-08
• [EN] MODULATION OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ACTIVITY<br/>[FR] MODULATION DE L'ACTIVITE DES RECEPTEURS ACTIVES PAR LES PROLIFERATEURS DE PEROXYSOMES
  申请人：CAREX SA

  公开号：WO2004037248A2

  公开（公告）日：2004-05-06

  The present invention relates to compounds, compositions and methods useful for modulating nuclear receptors activity in cells, and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors, including metabolic or cell proliferative disorders. According to particular aspects, the present invention relates to compounds, compositions and methods useful for modulating activities of the Peroxisome Proliferator Activated Receptors (PPARs) and for treating and/or preventing various diseases and conditions mediated by said nuclear receptors. More specifically, it relates to Peroxisome Proliferator Activated Receptor-gamma (PPAR-gamma) ligands, which are useful in the modulation of blood glucose levels and in the increase of insulin sensitivity in patients in need thereof. The properties of the compounds and compositions of the invention make these PPAR ligands particularly useful in the treatment of those diseases and conditions including diabetes, atherosclerosis, hyperglycemia, dyslipidemia, obesity, syndrome X, insulin resistance, hypertension, neuropathy, microvascular diseases (e.g. retinopathy, nephropathy), macrovascular diseases (e.g. myocardial infarction, stroke, heart failure) in mammals.