3,5-Dimethyl-4-pentan-2-yl-1,2-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,5-Dimethyl-4-pentan-2-yl-1,2-oxazole
• 英文别名: 3,5-dimethyl-4-pentan-2-yl-1,2-oxazole
• 化学式: C₁₀H₁₇NO
• 分子量: 167.25
• InChiKey: BVXBDTXDLVDHDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• PYRIMIDINE TRICYCLIC ENONE DERIVATIVES FOR INHIBITION OF ROR-GAMMA AND OTHER USES
  申请人：REATA PHARMACEUTICALS, INC.

  公开号：US20200131148A1

  公开（公告）日：2020-04-30

  Disclosed herein are compounds of the formulas: as well as analogs thereof, wherein the variables are defined herein. Also provided are pharmaceutical compositions thereof. In some aspects, the compounds and compositions provided herein may be used to inhibit RORγ and/or reduce the expression of IL-17. Also provided are methods of administering compounds and composition provided herein to a patient in need thereof, for example, for the treatment or prevention of diseases or disorders associated with inflammation or autoimmune disorders.