2-[1-[10-Methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-phenyl-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15,17,19-nonaen-11-yl]-3-[3-[2-[2-[2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-oxopropyl]piperidin-2-ylidene]acetic acid

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 2-[1-[10-Methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-phenyl-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15,17,19-nonaen-11-yl]-3-[3-[2-[2-[2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-oxopropyl]piperidin-2-ylidene]acetic acid
• 英文别名: 2-[1-[10-methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-phenyl-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15,17,19-nonaen-11-yl]-3-[3-[2-[2-[2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-3-oxopropyl]piperidin-2-ylidene]acetic acid
• 化学式: C₆₂H₇₁NO₁₄
• 分子量: 1054.2
• InChiKey: UBAKKARPFCUIPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.8
• 重原子数：
  77
• 可旋转键数：
  30
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  167
• 氢给体数：
  1
• 氢受体数：
  15

文献信息

• Ophthalmic devices comprising photochromic materials with reactive substituents
  申请人：Johnson and Johnson Vision Care, Inc.

  公开号：EP2270559A2

  公开（公告）日：2011-01-05

  Ophthalmic devices comprising photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates ophthalmic devices comprising photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety. Other non-limiting embodiments of the present disclosure relate to methods of making the photochromic ophthalmic device, wherein the photochromic ophthalmic devices comprise the photochromic naphthopyrans described herein.

  由包含活性取代基的光致变色材料组成的眼科设备。例如，本公开的眼科设备包含光致变色材料，如光致变色萘并吡喃和茚并融合萘并吡喃，这些材料具有活性取代基，活性取代基包括通过一个或多个连接基团与光致变色萘并吡喃连接的活性分子。在某些非限制性实施方案中，活性分子包括可聚合分子。在其它非限制性实施方案中，反应基包括亲核基。本公开的其它非限制性实施方案涉及光致变色眼科装置的制造方法，其中光致变色眼科装置包括本文所述的光致变色萘烷。
• Photochromic materials with reactive substituents
  申请人：Xiao Wenjing

  公开号：US20060226400A1

  公开（公告）日：2006-10-12

  Various non-limiting embodiments of the present disclosure relate to photochromic materials comprising a reactive substituent. For example, the present disclosure contemplates photochromic materials, such as photochromic naphthopyrans and indeno-fused naphthopyrans having a reactive substituent comprising a reactive moiety linked to the photochromic naphthopyran by one or more linking groups. In certain non-limiting embodiments, the reactive moiety comprises a polymerizable moiety. In other non-limiting embodiments, the reactive moiety comprises a nucleophilic moiety or an electrophilic moiety. Other non-limiting embodiments of the present disclosure relate to photochromic articles, compositions, and methods of making the photochromic articles, wherein the photochromic articles and compositions comprise the photochromic naphthopyrans described herein.

  本公开的各种非限制性实施方案涉及包含活性取代基的光致变色材料。例如，本公开涉及光致变色材料，如具有活性取代基的光致变色萘和茚并融合萘，活性取代基包括通过一个或多个连接基团与光致变色萘连接的活性分子。在某些非限制性实施方案中，活性分子包括可聚合分子。在其它非限制性实施方案中，反应基包括亲核基或亲电基。本公开的其它非限制性实施方案涉及光致变色物品、组合物和制造光致变色物品的方法，其中光致变色物品和组合物包括本文所述的光致变色萘并吡喃。
• PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS
  申请人：TRANSITIONS OPTICAL, INC.

  公开号：EP1866699B1

  公开（公告）日：2010-05-05
• OPHTHALMIC DEVICES COMPRISING PHOTOCHROMIC MATERIALS WITH REACTIVE SUBSTITUENTS
  申请人：Johnson and Johnson Vision Care, Inc.

  公开号：EP1872159A1

  公开（公告）日：2008-01-02
• US7556750B2
  申请人：——

  公开号：US7556750B2

  公开（公告）日：2009-07-07