tert-butyl 6-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate | 858351-42-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: tert-butyl 6-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate
• 英文别名: 1'-(tert-butoxycarbonyl)-1,2-dihydro-trifluoromethyl-spiro-3H-indole-3,4'-piperidine；tert-Butyl 6-trifluoromethylspiro[indoline-3,4'-piperidine]-1'-carboxylate；tert-butyl 6-(trifluoromethyl)spiro[1,2-dihydroindole-3,4'-piperidine]-1'-carboxylate
• CAS: 858351-42-5
• 化学式: C₁₈H₂₃F₃N₂O₂
• 分子量: 356.388
• InChiKey: ZJWOXHODESKIRT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-三氟甲基苯肼 在 sodium tetrahydroborate 、 乙醇 、 三氟乙酸 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 116.0h， 生成 tert-butyl 6-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate 、 tert-butyl 4-(trifluoromethyl)spiro[indoline-3,4'-piperidine]-1'-carboxylate
  参考文献：
  名称：

  [EN] SPIROINDOLINE ANTIPARASITIC DERIVATIVES
  [FR] DÉRIVÉS DE SPIROINDOLINE ANTIPARASITAIRES

  摘要：

  公开号：

  WO2015100232A3

文献信息

• Novel Spiroindoline or Spiroisoquinoline Compounds, Methods of Use and Compositions Thereof
  申请人：Boatman Douglas P.

  公开号：US20070254903A1

  公开（公告）日：2007-11-01

  The invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates and stereoisomers thereof, wherein A, B, E, G, W, X, Y, Z, o, and R 1 are as disclosed herein (“Compound(s) of the Invention”), which are useful as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.

  本发明提供了公式（I）的化合物及其药学上可接受的盐、溶剂合物和立体异构体，其中A、B、E、G、W、X、Y、Z、o和R1如本文所述（“本发明的化合物”），它们可用作心血管保护和/或神经保护剂。本发明还提供了包括本发明的化合物的制药组合物以及治疗、预防和/或管理血管、心血管或神经系统疾病或紊乱的方法，包括向需要该化合物的患者施用本发明的化合物。
• NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF
  申请人：Arena Pharmaceuticals, Inc.

  公开号：EP1716148A2

  公开（公告）日：2006-11-02
• SPIROINDOLINE ANTIPARASITIC DERIVATIVES
  申请人：Zoetis Services LLC

  公开号：EP3087072A2

  公开（公告）日：2016-11-02
• Spiroindoline Antiparasitic Derivatives
  申请人：ZOETIS SERVICES LLC

  公开号：US20160296499A1

  公开（公告）日：2016-10-13

  The invention describes novel spiropiperidines of Formula (1A), (1B), and (1C) stereoisomers thereof, veterinarily acceptable salts thereof, compositions thereof, processes for making, and their use in animals as an antiparasitic. The variables A, R 1 , R 2 , R 3 , R 4 , v, m, 5, and n are as described herein.
• [EN] NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF<br/>[FR] NOUVEAUX COMPOSES DE SPIROINDOLINE OU DE SPIROISOQUINOLINE, METHODES D'UTILISATION ET COMPOSITIONS ASSOCIEES
  申请人：ARENA PHARM INC

  公开号：WO2005063745A2

  公开（公告）日：2005-07-14

  The invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates and stereoisomers thereof, wherein A, B, E, G, W, X, Y, Z, o, and R1 are as disclosed herein (“Compound(s) of the Invention”), which are useful as cardio-protective and/or neuro-protective agents. The invention also provides pharmaceutical compositions comprising a Compound of the Invention and methods for treating, preventing and/or managing a vascular, cardiovascular or neurological disease or disorder, comprising administering to a patient in need thereof a Compound of the Invention.