diethyl (Z)-2-(acetylamino)-2-butenedioate | 1141496-88-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl (Z)-2-(acetylamino)-2-butenedioate
• 英文别名: Diethyl (z)-2-(acetylamino)-2-butenedioate；diethyl (Z)-2-acetamidobut-2-enedioate
• CAS: 1141496-88-9
• 化学式: C₁₀H₁₅NO₅
• 分子量: 229.233
• InChiKey: ZJYTVHRUEFLHTH-VURMDHGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙酰氨基丙二酸二乙酯 、 丙炔酸乙酯 在 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成 diethyl (Z)-2-(acetylamino)-2-butenedioate 、 triethyl (E)-(1-acetylamino)-2-propene-1,1,3-tricarboxylate
  参考文献：
  名称：

  Synthesis of polyfunctionalized alkenes and α,β-unsaturated γ-lactams from the reaction of alkyl propiolates and CH-acids such as diethyl acetamidomalonate and ethyl acetamidocyanoacetate in the presence of triphenylphosphine

  摘要：

  Dialkyl 1-(Z)-2-(acetylamino)-2-butenedioates, 1,1-diethyl-3-alkyl (E)-(1-acetylamino)-2-propene-1,1,3-tricarboxylate, 5-ethyl-1-methyl (E)-4-(acetylamino)-4-cyano-2-pentenedioate and ethyl 1-acetyl-2-cyano-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylate were obtained from the three-component reactions between alkyl propiolates and CH-acids such as diethyl acetamidomalonate and ethyl acetamidocyanoacetate in the presence of triphenylphosphine at room temperature in dry dichloromethane.

  DOI：

  10.1007/s00706-008-0904-6

文献信息

• Synthesis of polyfunctionalized alkenes and α,β-unsaturated γ-lactams from the reaction of alkyl propiolates and CH-acids such as diethyl acetamidomalonate and ethyl acetamidocyanoacetate in the presence of triphenylphosphine
  作者：Sakineh Asghari、Azin Salimi、Mohammad Qandalee

  DOI：10.1007/s00706-008-0904-6

  日期：2008.10

  Dialkyl 1-(Z)-2-(acetylamino)-2-butenedioates, 1,1-diethyl-3-alkyl (E)-(1-acetylamino)-2-propene-1,1,3-tricarboxylate, 5-ethyl-1-methyl (E)-4-(acetylamino)-4-cyano-2-pentenedioate and ethyl 1-acetyl-2-cyano-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylate were obtained from the three-component reactions between alkyl propiolates and CH-acids such as diethyl acetamidomalonate and ethyl acetamidocyanoacetate in the presence of triphenylphosphine at room temperature in dry dichloromethane.