3-Ethylamino-4-nitro-pyridin | 13505-04-9

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 3-Ethylamino-4-nitro-pyridin
• 英文别名: ethyl-(4-nitro-pyridin-3-yl)-amine；4-Nitro-3-ethylaminopyridine；N-ethyl-4-nitropyridin-3-amine
• CAS: 13505-04-9
• 化学式: C₇H₉N₃O₂
• 分子量: 167.167
• InChiKey: KAGLMULMXQYOKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  70.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-Ethylamino-4-nitro-pyridin 在 palladium on activated charcoal 氢气 作用下， 生成 N3-乙基-3,4-吡啶二胺
  参考文献：
  名称：

  (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

  摘要：

  A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.021
• 作为产物：
  描述：

  3-methoxy-4-nitropyridine hydrochloride 、 乙胺 以 乙醇 为溶剂， 生成 3-Ethylamino-4-nitro-pyridin
  参考文献：
  名称：

  (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors

  摘要：

  A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.05.021

文献信息

• (1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: A novel class of potent MSK-1-inhibitors
  作者：Mark J. Bamford、Michael J. Alberti、Nicholas Bailey、Susannah Davies、David K. Dean、Alessandra Gaiba、Stephen Garland、John D. Harling、David K. Jung、Terence A. Panchal、Christopher A. Parr、Jon G. Steadman、Andrew K. Takle、James T. Townsend、David M. Wilson、Jason Witherington

  DOI：10.1016/j.bmcl.2005.05.021

  日期：2005.7

  A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. (c) 2005 Elsevier Ltd. All rights reserved.