A Novel Synthesis of 1,3-Oxazine-2,4-diones via a Simple and Efficient Reaction of CO2 with 2,3-Allenamides
摘要:
A simple and efficient reaction of CO2 with 2,3-allenamides under mild conditions (CO2 balloon without any metal catalyst in the presence of K2CO3 or Cs2CO3) leads to an efficient synthesis of 1,3-oxazine-2,4-diones. The high reactivity of the allene moiety is crucial for the success of this transformation since the corresponding reaction of alpha,beta-unsaturated alkenamides or alkynamides does not occur.
A Novel Synthesis of 1,3-Oxazine-2,4-diones via a Simple and Efficient Reaction of CO<sub>2</sub> with 2,3-Allenamides
作者:Guofei Chen、Chunling Fu、Shengming Ma
DOI:10.1021/ol9009046
日期:2009.7.2
A simple and efficient reaction of CO2 with 2,3-allenamides under mild conditions (CO2 balloon without any metal catalyst in the presence of K2CO3 or Cs2CO3) leads to an efficient synthesis of 1,3-oxazine-2,4-diones. The high reactivity of the allene moiety is crucial for the success of this transformation since the corresponding reaction of alpha,beta-unsaturated alkenamides or alkynamides does not occur.