dimethyl (2R,7R)-2,7-diamino-2,7-dipropargyl-4-octynedioate | 429674-37-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: dimethyl (2R,7R)-2,7-diamino-2,7-dipropargyl-4-octynedioate
• 英文别名: dimethyl (2R,7R)-2,7-diamino-2,7-bis(prop-2-ynyl)oct-4-ynedioate
• CAS: 429674-37-3
• 化学式: C₁₆H₂₀N₂O₄
• 分子量: 304.346
• InChiKey: NQUAWCDXOAFESL-HZPDHXFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  乙酸酐 、 dimethyl (2R,7R)-2,7-diamino-2,7-dipropargyl-4-octynedioate 在 4-二甲氨基吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以95%的产率得到dimethyl (2R,7R)-2,7-diacetamido-2,7-dipropargyl-4-octynedioate
  参考文献：
  名称：

  Ru(II)-Catalyzed Cascade Reactions in Stereocontrolled Construction of Rigid as-Indacene-Bridged Bis(α-amino acid) Derivatives

  摘要：

  The key construction in the preparation of as-indacene-bridged bis(a-amino acid) derivatives was effected by a Ru(II)-catalyzed RCM cascade reaction of appropriately substituted triynes. The latter were available after stepwise and stereocontrolled alkynylations of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine as chiral auxiliary. The regio- and stereochemical transformations have been verified by a single-crystal X-ray analysis.

  DOI：

  10.1021/jo010888p
• 作为产物：
  描述：

  1,4-bis[(2R,5S)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazin-5-yl]-2-butyne 在 正丁基锂 、 四丁基氟化铵 、 三氟乙酸 作用下， 以 四氢呋喃 、 正己烷 、 水 、 乙腈 为溶剂， 反应 97.17h， 生成 dimethyl (2R,7R)-2,7-diamino-2,7-dipropargyl-4-octynedioate
  参考文献：
  名称：

  Ru(II)-Catalyzed Cascade Reactions in Stereocontrolled Construction of Rigid as-Indacene-Bridged Bis(α-amino acid) Derivatives

  摘要：

  The key construction in the preparation of as-indacene-bridged bis(a-amino acid) derivatives was effected by a Ru(II)-catalyzed RCM cascade reaction of appropriately substituted triynes. The latter were available after stepwise and stereocontrolled alkynylations of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine as chiral auxiliary. The regio- and stereochemical transformations have been verified by a single-crystal X-ray analysis.

  DOI：

  10.1021/jo010888p

文献信息

• Ru(II)-Catalyzed Cascade Reactions in Stereocontrolled Construction of Rigid <i>as</i>-Indacene-Bridged Bis(α-amino acid) Derivatives
  作者：Gunn Beate Hoven、Jon Efskind、Christian Rømming、Kjell Undheim

  DOI：10.1021/jo010888p

  日期：2002.4.1

  The key construction in the preparation of as-indacene-bridged bis(a-amino acid) derivatives was effected by a Ru(II)-catalyzed RCM cascade reaction of appropriately substituted triynes. The latter were available after stepwise and stereocontrolled alkynylations of (2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine as chiral auxiliary. The regio- and stereochemical transformations have been verified by a single-crystal X-ray analysis.