5-(trifluoromethoxy)oxyindole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-(trifluoromethoxy)oxyindole
• 英文别名: 5-(trifluoromethylperoxy)-1H-indole
• 化学式: C₉H₆F₃NO₂
• 分子量: 217.147
• InChiKey: NUPOMIUJLFKPNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-(trifluoromethoxy)oxyindole 在 三氯氧磷 作用下， 以17 %的产率得到2-chloro-5-(trifluoromethoxy)-1H-indole-3-carboxaldehyde
  参考文献：
  名称：

  ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES

  摘要：

  The present disclosure relates to a pharmaceutical composition for preventing or treating an inflammatory disease, comprising a benzofuran-based N-acylhydrazone compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The benzofuran-based N-acylhydrazone compound according to the present disclosure inhibits the activity of NF-κB, which is a major signal transmitter in the inflammatory response, thereby disrupting the initial pathway and process of the biological inflammatory response system and inhibiting inflammatory immune cells and inflammatory cytokines, and thus can prevent and treat various pathological diseases caused by the inflammatory response.

  公开号：

  US20230293487A1
• 作为产物：
  描述：

  5-三氟甲氧基吲哚-2,3-二酮 在 potassium penicillin V 、 一水合肼 作用下， 以52 %的产率得到5-(trifluoromethoxy)oxyindole
  参考文献：
  名称：

  ANTI-INFLAMMATORY COMPOSITION COMPRISING BENZOFURAN-BASED N-ACYLHYDRAZONE DERIVATIVES

  摘要：

  The present disclosure relates to a pharmaceutical composition for preventing or treating an inflammatory disease, comprising a benzofuran-based N-acylhydrazone compound, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The benzofuran-based N-acylhydrazone compound according to the present disclosure inhibits the activity of NF-κB, which is a major signal transmitter in the inflammatory response, thereby disrupting the initial pathway and process of the biological inflammatory response system and inhibiting inflammatory immune cells and inflammatory cytokines, and thus can prevent and treat various pathological diseases caused by the inflammatory response.

  公开号：

  US20230293487A1