5-methyl-4-(2-methylpropyl)-1H-pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-4-(2-methylpropyl)-1H-pyrazole
• 化学式: C₈H₁₄N₂
• 分子量: 138.21
• InChiKey: ADLFQPFMUTUCJM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• INHIBITORS OF KINASE NETWORKS AND USES THEREOF
  申请人：PURDUE RESEARCH FOUNDATION

  公开号：US20210371420A1

  公开（公告）日：2021-12-02

  The present invention generally relates to compounds as a dual kinase-demethylase inhibitor useful for the treatment of diseases mediated by a kinase and/or a histone demethylase, such as inflammation, cancer, viral and bacterial infections, neurological and immunological disorders. Pharmaceutical compositions and methods for treating those diseases are within the scope of this invention.
• QUINOLINE INHIBITORS OF RAD52 AND METHODS OF USE
  申请人：Drexel University

  公开号：US20220388980A1

  公开（公告）日：2022-12-08

  The present disclosure related to compounds of Formula I and Formula I and to their pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating RAD52 activity and may be used in the treatment of disorders in which RAD52 activity is implication, such as a cancer.