1-[5-Hydroxy-2-methyl-1-(3-vinyloxy-propyl)-1H-indol-3-yl]-ethanone

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-[5-Hydroxy-2-methyl-1-(3-vinyloxy-propyl)-1H-indol-3-yl]-ethanone
• 英文别名: 1-[1-(3-Ethenoxypropyl)-5-hydroxy-2-methylindol-3-yl]ethanone
• 化学式: C₁₆H₁₉NO₃
• 分子量: 273.332
• InChiKey: WXUYGLNJCBHXBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  51.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-氨基-1-丙醇乙烯基醚 以 丙酮 为溶剂， 反应 3.0h， 生成 1-[5-Hydroxy-2-methyl-1-(3-vinyloxy-propyl)-1H-indol-3-yl]-ethanone
  参考文献：
  名称：

  Synthesis of 5-hydroxy-N-(2-vinyloxyalkyl)indoles from dicarbonyl compounds and vinyloxyalkylamines

  摘要：

  N-(Vinyloxyalkyl)enaminoketones were obtained by the condensation of vinyloxyalkyl-amines with acetylacetone or ethyl acetoacetate. Their subsequent reactions with 1,4-benzoquinone produce the corresponding 5-hydroxy-2-methyl-N-(2-vinyloxyalkyl)indoles in 17-43% yields. The structures of the compounds obtained were confirmed by IR and H-1 NMR spectroscopy.

  DOI：

  10.1007/bf02495263