2-{2-[(2,4-Dichlorophenyl)amino]-4-(4-methylphenyl)-1,3-thiazol-5-YL}acetic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-{2-[(2,4-Dichlorophenyl)amino]-4-(4-methylphenyl)-1,3-thiazol-5-YL}acetic acid
• 英文别名: 2-[2-(2,4-dichloroanilino)-4-(4-methylphenyl)-1,3-thiazol-5-yl]acetic acid
• 化学式: C₁₈H₁₄Cl₂N₂O₂S
• mdl: MFCD03274497
• 分子量: 393.3
• InChiKey: JLYNGMUQVIZMEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  90.5
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS
  申请人：Verkman Alan S.

  公开号：US20110015239A1

  公开（公告）日：2011-01-20

  Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequalae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.
• US9789095B2
  申请人：——

  公开号：US9789095B2

  公开（公告）日：2017-10-17
• [EN] INHIBITORS OF CALCIUM-ACTIVATED CHLORIDE CHANNELS<br/>[FR] INHIBITEURS DES CANAUX CHLORURE ACTIVES PAR LE CALCIUM
  申请人：UNIV CALIFORNIA

  公开号：WO2009079373A2

  公开（公告）日：2009-06-25

  Provided herein are methods for identifying compounds that are inhibitors of a calcium-activated chloride channel. Aminothiophene and aminothiazole compounds, and compositions comprising these compounds, described herein that inhibit efflux of chloride through a calcium-activated chloride channel are useful for treating diseases, disorders, and sequelae of diseases, disorders, and conditions that are associated with aberrantly increased chloride and fluid secretion, for example, secretory diarrhea.