5-methyl-N-(5-nitro-1,3-thiazol-2-yl)-3-phenyl-1,2-oxazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-methyl-N-(5-nitro-1,3-thiazol-2-yl)-3-phenyl-1,2-oxazole-4-carboxamide
• 化学式: C14H10N4O4S
• 分子量: 330.32
• InChiKey: UYYQKLFHMYQRSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• [EN] INHIBITORS OF GLUTATHIONE S-TRANSFERASES (GSTS) AND NAD(P)H:QUINONE OXIDOREDUCTASE 1 (NQO1), PHARMACEUTICAL COMPOSITIONS, AND USES IN MANAGING CANCER<br/>[FR] INHIBITEURS DE GLUTATHION S-TRANSFÉRASES (GST) ET DE NAD(P)H:QUINONE OXYDORÉDUCTASE 1 (NQO1), COMPOSITIONS PHARMACEUTIQUES ET UTILISATIONS DANS LA GESTION DU CANCER
  申请人：UNIV EMORY

  公开号：WO2021150756A1

  公开（公告）日：2021-07-29

  This disclosure relates to compounds that inhibit glutathione S-transferases (GSTs) and/or NAD(P)H:quinone oxidoreductase 1 (NQO1) for uses in treating cancer. In certain embodiments, this disclosure relates to compositions and uses of N-(thiazol-2-yl)-carboxamide derivatives such as a N-(5-nitrothiazol-2-yl)-carboxamide derivatives for treating cancer such as glioblastoma. In certain embodiments, this disclosure relates to pharmaceutical compositions comprising a N-(thiazol-2-yl)-carboxamide derivative such as a N-(5-nitrothiazol-2-yl)-carboxamide derivative which is a compound of formula (I), or derivative, prodrug or salt thereof and a pharmaceutically acceptable excipient, wherein X, R1, R2, and R3 substituents are reported herein.