5-(3,5-Dimethylphenyl)-1,3-oxazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(3,5-Dimethylphenyl)-1,3-oxazole
• 英文别名: 5-(3,5-dimethylphenyl)-1,3-oxazole
• 化学式: C₁₁H₁₁NO
• 分子量: 173.21
• InChiKey: DRTQNQUAOTUFPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Benzylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20190241521A1

  公开（公告）日：2019-08-08

  The present invention relates to compounds of general formula I, wherein the groups R, R 1 , R 2 , R 3 , m and n are defined herein, which have valuable pharmacological properties, including binding to the GPR40 receptor and modulating its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2. Furthermore, the invention relates to novel intermediates, useful for the synthesis of compounds of formula I.