4-[(4,5-Dimethyl-1,3-thiazol-2-yl)amino]-4-oxobut-2-enoic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[(4,5-Dimethyl-1,3-thiazol-2-yl)amino]-4-oxobut-2-enoic acid
• 化学式: C₉H₁₀N₂O₃S
• 分子量: 226.25
• InChiKey: NLPJFIDVGGRSEB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF
  申请人：HSF Pharmaceuticals

  公开号：EP3512602A2

  公开（公告）日：2019-07-24
• Inhibitors of heat shock factors and uses thereof
  申请人：Vilaboa Nuria

  公开号：US20210221778A1

  公开（公告）日：2021-07-22

  The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.
• [EN] INHIBITORS OF HEAT SHOCK FACTORS AND USES THEREOF<br/>[FR] INHIBITEURS DU FACTEUR DE CHOC THERMIQUE ET UTILISATIONS DE CEUX-CI
  申请人：HSF PHARMACEUTICALS

  公开号：WO2018050656A2

  公开（公告）日：2018-03-22

  The present disclosure relates to a class of mammalian heat shock factor (HSF) inhibitors, to pharmaceutical compositions comprising these inhibitors as well as to methods for using the inhibitors. The inhibitors inhibit stress-induced expression from heat shock gene promoters. Furthermore, the inhibitors are cytotoxic to a variety of human cancer cells types.