1-(2-Methylbutyl)triazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(2-Methylbutyl)triazole
• 英文别名: 1-(2-methylbutyl)triazole
• 化学式: C₇H₁₃N₃
• 分子量: 139.2
• InChiKey: HZZQGQQBLHLXAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] SMALL MOLECULE MENIN INHIBITORS<br/>[FR] INHIBITEURS DE MÉNINE À PETITES MOLÉCULES
  申请人：UNIV MICHIGAN REGENTS

  公开号：WO2020072391A1

  公开（公告）日：2020-04-09

  The present disclosure provides compounds represented by Formula I: and the pharmaceutically acceptable salts and solvates thereof, wherein R1a, R1b, R1c, E, G, and Q are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat cancer or any other disease, condition, or disorder that is responsive to inhibition of menin.

  本公开提供由以下公式I表示的化合物及其药用可接受的盐和溶剂化物，其中R1a、R1b、R1c、E、G和Q的定义如规范中所述。本公开还提供公式I的化合物用于治疗癌症或对抑制menin敏感的任何其他疾病、症状或障碍。
• Antimicrobial Compounds And Methods Of Making And Using The Same
  申请人：Melinta Therapeutics, Inc.

  公开号：US20180065966A1

  公开（公告）日：2018-03-08

  The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals.