N-(3-amino-2-hydroxypropyl)octadecanamide | 114000-81-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: N-(3-amino-2-hydroxypropyl)octadecanamide
• CAS: 114000-81-6
• 化学式: C₂₁H₄₄N₂O₂
• 分子量: 356.593
• InChiKey: DSFQWMOIVCWCAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  25
• 可旋转键数：
  19
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  75.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,3-二氯-2-丙基十八烷酸酯 在 sodium azide 、 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 72.0h， 生成 N-(3-amino-2-hydroxypropyl)octadecanamide
  参考文献：
  名称：

  Synthesis and Thermophysical Characterization of Fatty Amides for Thermal Energy Storage

  摘要：

  从羧酸（C8-C18）和原油甘油中合成了九种单酰胺。最终的单酰胺是在最终氢化过程中酰基链的重排结果。使用光谱学和质谱技术确定了最终化合物的纯度。研究了固态单酰胺的热物理性质，以确定它们作为相变材料（PCM）在热能储存中的能力。使用差示扫描量热仪（DSC）确定了热物理性质。所分析材料的熔点范围从62.2℃到116.4℃。这些单酰胺的分析焓范围为25.8 kJ/kg到149.7 kJ/kg。焓值的分析考虑了碳链和氢键的形成。

  DOI：

  10.3390/molecules24203777

文献信息

• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI Bio, Inc.

  公开号：EP3229811B1

  公开（公告）日：2021-02-24
• [EN] OLIGONUCLEOTIDE MICELLES<br/>[FR] MICELLES OLIGONUCLÉOTIDIQUES
  申请人：UNIV FLORIDA

  公开号：WO2010071852A2

  公开（公告）日：2010-06-24

  The present invention provides homogenous populations of micelles, methods for preparing these populations, methods for treating or preventing a disease or disorder using the population of micelles of the invention.
• [EN] PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS<br/>[FR] PRÉVENTION ET TRAITEMENT DE PATHOLOGIES INFLAMMATOIRES
  申请人：GLYCOREGIMMUNE INC

  公开号：WO2016094226A1

  公开（公告）日：2016-06-16

  In accordance with some embodiments herein, methods and compositions for prevention and treatment of inflammatory conditions are provided. In some embodiments, compositions comprising NKT-2 activators, for example miltefosine are provided. In some embodiments, the compositions further comprise sulfatide and/or a RAR agonist. In some embodiments, the compositions comprise activators of Type II NKT cells, and/or inhibitors of Type I NKT cells.
• [EN] METHODS FOR IDENTIFYING CHIMERIC ANTIGEN RECEPTOR-TARGETING LIGANDS AND USES THEREOF<br/>[FR] PROCÉDÉS D'IDENTIFICATION DE LIGANDS DE CIBLAGE DE RÉCEPTEUR ANTIGÉNIQUE CHIMÉRIQUE ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2021221783A1

  公开（公告）日：2021-11-04

  The disclosure features chimeric antigen receptor (CAR) ligands, methods for making the same, and immunomodulatory compositions comprising the CAR ligands. The disclosure also features compositions and methods of using the immunomodulatory compositions, for example, to stimulate activation of CAR expressing cells.
• Synthesis and Thermophysical Characterization of Fatty Amides for Thermal Energy Storage
  作者：Anna Canela-Xandri、Gemma Villorbina、Mercè Balcells、Xavier Fernández-Francos、Luisa F. Cabeza、Ramon Canela-Garayoa

  DOI：10.3390/molecules24203777

  日期：——

  Nine monoamides were synthesized from carboxylic acids (C8–C18) and crude glycerol. The final monoamides were the result of a rearrangement of the acyl chain during the final hydrogenation process. The purity of the final compounds was determined by spectroscopic and mass spectrometry (MS) techniques. The thermophysical properties of solid monoamides were investigated to determine their capability to act as phase change materials (PCM) in thermal energy storage. Thermophysical properties were determined with a differential scanning calorimeter (DSC). The melting temperatures of the analyzed material ranged from 62.2 °C to 116.4 °C. The analyzed enthalpy of these monoamides ranged from 25.8 kJ/kg to 149.7 kJ/kg. Enthalpy values are analyzed considering the carbon chain and the formation of hydrogen bonds.

  从羧酸（C8-C18）和原油甘油中合成了九种单酰胺。最终的单酰胺是在最终氢化过程中酰基链的重排结果。使用光谱学和质谱技术确定了最终化合物的纯度。研究了固态单酰胺的热物理性质，以确定它们作为相变材料（PCM）在热能储存中的能力。使用差示扫描量热仪（DSC）确定了热物理性质。所分析材料的熔点范围从62.2℃到116.4℃。这些单酰胺的分析焓范围为25.8 kJ/kg到149.7 kJ/kg。焓值的分析考虑了碳链和氢键的形成。