N-tert-butyl-2-[(2-chlorophenyl)methyl-[2-[5-(3,4-dimethoxyphenyl)tetrazol-2-yl]acetyl]amino]-2-thiophen-2-ylacetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-tert-butyl-2-[(2-chlorophenyl)methyl-[2-[5-(3,4-dimethoxyphenyl)tetrazol-2-yl]acetyl]amino]-2-thiophen-2-ylacetamide
• 化学式: C₂₈H₃₁ClN₆O₄S
• 分子量: 583.1
• InChiKey: QSNAZNWAWFBWQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  140
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• [EN] COMPETITORS OF MICROPHTHALMIA TRANSCRIPTION FACTOR AND THE COSMETIC COMPOSITION COMPRISING THEREOF<br/>[FR] COMPÉTITEURS DE FACTEUR DE TRANSCRIPTION ASSOCIÉ À LA MICROPHTALMIE ET COMPOSITION COSMÉTIQUE LES CONTENANT
  申请人：INHA IND PARTNERSHIP INST

  公开号：WO2009020267A1

  公开（公告）日：2009-02-12

  The present invention relates to MITF (microphthalmia transcription factor) competitors, precisely MITF competitors selected by using the protein chip for screening MITF competitors being able to suppress the expression of pigmentation related enzymes by inhibiting the binding of MITF with promoter of the pigmentation related enzyme gene and a cosmetic composition for whitening comprising the same. The composition of the present invention has skin whitening activity but no cytotoxicity, so that it can be effectively used for cosmetics for skin whitening or as a whitening agent.