4-[[1-[(6-Chloropyridin-3-yl)methyl]triazol-4-yl]methoxy]benzaldehyde | 1191128-50-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[[1-[(6-Chloropyridin-3-yl)methyl]triazol-4-yl]methoxy]benzaldehyde
• CAS: 1191128-50-3
• 化学式: C₁₆H₁₃ClN₄O₂
• 分子量: 328.758
• InChiKey: PADTWKKOTCRMIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  69.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-5-氯甲基吡啶 、 4-(丙-2-炔-1-基氧基)苯甲醛 在 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以77%的产率得到4-[[1-[(6-Chloropyridin-3-yl)methyl]triazol-4-yl]methoxy]benzaldehyde
  参考文献：
  名称：

  铜流反应器技术在1,4-二取代1,2,3-三唑连续合成中的应用

  摘要：

  Abstractmagnified imageA library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper‐catalyzed Huisgen 1,3‐dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.

  DOI：

  10.1002/adsc.200800758

文献信息

• The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles
  作者：Andrew R. Bogdan、Neal W. Sach

  DOI：10.1002/adsc.200800758

  日期：2009.4

  Abstractmagnified imageA library of 1,4‐disubstituted 1,2,3‐triazoles was synthesized using a copper flow reactor. Organic azides, generated in situ from alkyl halides and sodium azide, were reacted with acetylenes using the copper‐catalyzed Huisgen 1,3‐dipolar cycloaddition. This process eliminates both the handling of organic azides and the need for additional copper catalyst and permits the facile preparation of numerous triazoles in a continuous flow process.