5-(2,5-dimethoxyphenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)isoxazole-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(2,5-dimethoxyphenyl)-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)isoxazole-3-carboxamide
• 英文别名: 5-(2,5-dimethoxyphenyl)-N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-1,2-oxazole-3-carboxamide
• 化学式: C₂₃H₂₂N₄O₅
• mdl: MFCD09782482
• 分子量: 434.4
• InChiKey: QSOQSIICGFSJQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  97.1
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• CARBOXAMIDE INHIBITORS
  申请人：Norvartis AG

  公开号：US20170088545A1

  公开（公告）日：2017-03-30

  The present invention provides a compound of formula I The compounds of formula I demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, particularly pulmonary arterial hypertension.
• [EN] CARBOXAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS DE CARBOXAMIDE
  申请人：NOVARTIS AG

  公开号：WO2015173656A1

  公开（公告）日：2015-11-19

  The present invention provides a compound of formula (I) and/or a pharmaceutically acceptable salt thereof. The compounds of formula (I) (and/or their pharmaceutically acceptable salts) demonstrate properties as Smurf-1 inhibitors and are thus useful in the treatment of a range of disorders, such as, for example, pulmonary arterial hypertension, fibrosis, rheumatoid arthritis, fracture healing, glaucoma, hereditary hemorrhagic telangiectasia (HHT), proteinuria, wound healing, COPD, and/or asthma.