N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-1-[[5-methyl-2-(2-methylphenyl)-4-oxazolyl]methyl]-4-piperidinecarboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[3-(3,5-dimethyl-1-piperidinyl)propyl]-1-[[5-methyl-2-(2-methylphenyl)-4-oxazolyl]methyl]-4-piperidinecarboxamide
• 英文别名: N-[3-(3,5-dimethylpiperidin-1-yl)propyl]-1-[[5-methyl-2-(2-methylphenyl)-1,3-oxazol-4-yl]methyl]piperidine-4-carboxamide
• 化学式: C₂₈H₄₂N₄O₂
• 分子量: 466.7
• InChiKey: MRHJNIMUABLZHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEURS MÉTHODES D'UTILISATION
  申请人：US HEALTH

  公开号：WO2015192077A1

  公开（公告）日：2015-12-17

  Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.

  公开的是以下化合物的结构：式(I)、式(II)和式(III)，其中Ar、R1、A和X的定义如规范中所述。这些化合物是抗病毒剂，可用于治疗病毒感染，例如丙型肝炎。这些化合物也可用于治疗或预防癌症。
• Heterocyclic compounds and methods of use thereof
  申请人：The United States of America, as represented by the Secretary, Department of Health and Human Services

  公开号：US10202367B2

  公开（公告）日：2019-02-12

  Disclosed are compounds of formula (I), formula (II), and formula (III): wherein Ar, R1, A, and X are as defined in the specification. These compounds are antiviral agents and are contemplated for use in the treatment of viral infections, for example, hepatitis C. These compounds are also contemplated for use in treating or preventing cancers.

  公开了式(I)、式(II)和式(III)化合物：其中 Ar、R1、A 和 X 如说明书中所定义。这些化合物是抗病毒剂，可用于治疗病毒感染，例如丙型肝炎。
• HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The U.S.A. as represented by the Secretary, Department of Health and Human Services

  公开号：EP3154966B1

  公开（公告）日：2019-05-08