[3-ethyl-5-(2-fluorophenyl)-1-[4-(N'-hydroxycarbamimidoyl)phenyl]pyrazol-4-yl] hydrogen carbonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: [3-ethyl-5-(2-fluorophenyl)-1-[4-(N'-hydroxycarbamimidoyl)phenyl]pyrazol-4-yl] hydrogen carbonate
• 化学式: C₁₉H₁₇FN₄O₄
• 分子量: 384.4
• InChiKey: ZYQGFVGGIFQJGD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  123
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] PYRAZOLE DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS<br/>[FR] DERIVES PYRAZOLE INHIBITEURS DE TRANSPORT DE GLYCINE
  申请人：MERCK PATENT GMBH

  公开号：WO2003031435A1

  公开（公告）日：2003-04-17

  Compounds of the formula (I) and salts and solvates thereof, in which X, R?1, R2, R3, R4 and R5¿ are as defined in Claim 1, are suitable as glycine transporter inhibitors and can be used in human and veterinary medicine for the prophylaxis and treatment of schizophrenia, depression, dementia, Parkinson's disease, Alzheimer's disease, Lewy bodies dementia, Huntington's disease, Tourette's syndrome, anxiety, learning and memory restrictions, neurodegenerative disorders and other cognitive impairments, as well as nicotine dependence and pain.